ID A0A3M8ECS7_9BACT Unreviewed; 808 AA.
AC A0A3M8ECS7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Endonuclease MutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_00092};
GN Name=mutS2 {ECO:0000256|HAMAP-Rule:MF_00092};
GN ORFNames=D7D25_13775 {ECO:0000313|EMBL:RNC63909.1};
OS Proteiniphilum sp. X52.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Proteiniphilum.
OX NCBI_TaxID=2382159 {ECO:0000313|EMBL:RNC63909.1, ECO:0000313|Proteomes:UP000272792};
RN [1] {ECO:0000313|EMBL:RNC63909.1, ECO:0000313|Proteomes:UP000272792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X52 {ECO:0000313|EMBL:RNC63909.1,
RC ECO:0000313|Proteomes:UP000272792};
RA Hivarkar S., Lanjekar V.B., Dhakephalkar P.K., Dagar S.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Endonuclease that is involved in the suppression of
CC homologous recombination and may therefore have a key role in the
CC control of bacterial genetic diversity. {ECO:0000256|HAMAP-
CC Rule:MF_00092}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MutS2
CC subfamily. {ECO:0000256|HAMAP-Rule:MF_00092}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNC63909.1}.
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DR EMBL; RDSD01000020; RNC63909.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8ECS7; -.
DR OrthoDB; 9808166at2; -.
DR Proteomes; UP000272792; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR GO; GO:0045910; P:negative regulation of DNA recombination; IEA:InterPro.
DR CDD; cd06503; ATP-synt_Fo_b; 1.
DR Gene3D; 3.30.1370.110; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00092; MutS2; 1.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR046893; MSSS.
DR InterPro; IPR005747; MutS2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002625; Smr_dom.
DR InterPro; IPR036063; Smr_dom_sf.
DR NCBIfam; TIGR01069; mutS2; 1.
DR PANTHER; PTHR48378:SF1; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR48378; DNA MISMATCH REPAIR PROTEINS MUTS FAMILY DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR Pfam; PF20297; MSSS; 1.
DR Pfam; PF00488; MutS_V; 1.
DR Pfam; PF01713; Smr; 1.
DR PIRSF; PIRSF005814; MutS_YshD; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SMART; SM00463; SMR; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF160443; SMR domain-like; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
DR PROSITE; PS50828; SMR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00092};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759, ECO:0000256|HAMAP-
KW Rule:MF_00092}; Hydrolase {ECO:0000256|HAMAP-Rule:MF_00092};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00092};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00092}.
FT DOMAIN 733..808
FT /note="Smr"
FT /evidence="ECO:0000259|PROSITE:PS50828"
FT REGION 625..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 533..610
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 345..352
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00092"
SQ SEQUENCE 808 AA; 91868 MW; 4322AD283D42B34F CRC64;
MIYPDNFEQK IEFQKVRQLL SERCLSPLGK EKVEEMHFSA SYGEIEPLLF QTEEFVRIGE
EEDSFPADHF YDMRPVLRRI RVEGAWIDQN ALFELRRSLQ TIHGIVAFLR RDEGKAPKYP
YLLALAGGIP TFPEMTRRID SILDGFGQVK DHASPRLSEI RRELTSTLNG ISKSLNAILR
KAQAEGYVDK DVSPSMRDGR LVIPVNPSHK RKIKGIVHDE SASGKTVFIE PSEVVEANNR
IRELEADERR EIIKILTDFT NYLRPSLPDL LESYEFLAKI DFIQAKAAFA RLIGGIKPSI
DNTPRIDWVE AVHPLLYLSL KKQNRKIVPL DIILEGDNRL LVISGPNAGG KSVCLKTVGL
LQYMVQCGLL IPLKENSRVG VFDDIFIDIG DEQSIENDLS TYSSHLLNMK FFEKHCNDKS
LLLIDEFGSG TEPRIGAAIA EALLDRFNRR QSFGVITTHY QNLKHFANEN EGVVNGAMLY
DRHEMQPLFR LAIGNPGSSF AVEIARKTGI PEDVIAHASE IVGKDYIDMD KYLQDISRDK
RYWERKRDEI RRERKRLEEI TSKYEADLET IHKQKKEILA QAREQAERLL AESNARIENT
IREIREAGAD KEKTKQIRQS LREFKEKMEP VDMPETKKRK KQKQRRTAGD DNGLKAAQPL
AAGDTVRLIG QSSPGEIMEI SGKKAVVAFG MIKSTVDLDK LERVSANQIK KERKVSNTRD
LLHERKLNFK QDIDVRGMRG DEALQAVMYF VDDAIQLGVS RVRILHGTGT GALRQVIREY
LGSVHGVARF QDEHVQFGGA GITVVDLE
//
