ID A0A3M8EFI2_9BACT Unreviewed; 366 AA.
AC A0A3M8EFI2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=D7D25_16850 {ECO:0000313|EMBL:RNC63374.1};
OS Proteiniphilum sp. X52.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC Proteiniphilum.
OX NCBI_TaxID=2382159 {ECO:0000313|EMBL:RNC63374.1, ECO:0000313|Proteomes:UP000272792};
RN [1] {ECO:0000313|EMBL:RNC63374.1, ECO:0000313|Proteomes:UP000272792}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X52 {ECO:0000313|EMBL:RNC63374.1,
RC ECO:0000313|Proteomes:UP000272792};
RA Hivarkar S., Lanjekar V.B., Dhakephalkar P.K., Dagar S.;
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNC63374.1}.
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DR EMBL; RDSD01000034; RNC63374.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8EFI2; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000272792; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RNC63374.1};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 54..100
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 116..328
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 366 AA; 42002 MW; B97354BF4A93D69A CRC64;
MKRTDKEEDL IHPISSGKIA RILNDPQKTA KAVNLVYVCD DQPGIIREKR GKTFRYFLDG
KEVKNKQVLE RIRKLVIPPA WEEVWICALE NGHLQATGID AAKRKQYRYH PAWVALRNHT
KYYRMVQFAH ALPHIRAKVE KDLARHGLPR EKVLAAVVSL MERTNMRVGN SSYERLYGSF
GLTTLKDKHI DVKGNAIRFS FKGKKGVHQD ITLRNAKLAR IVQRCKEIPG KELFQYYDEE
GKRQTIDSGM VNDYIREVGG EDFTAKDFRT WGGTVNAFLA LSELGCGETQ NEQKKKVVEA
LDKVAACLGN TRAVCKKYYV HPLIISLYEN GSLQEYFEQF DKIEENDNRT GLTKEEKIIL
SILEKG
//
