ID   A0A3M8EHZ8_9BACT        Unreviewed;       460 AA.
AC   A0A3M8EHZ8;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Multidrug export protein MepA {ECO:0000256|ARBA:ARBA00022106};
GN   ORFNames=D7D25_12780 {ECO:0000313|EMBL:RNC64244.1};
OS   Proteiniphilum sp. X52.
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Dysgonomonadaceae;
OC   Proteiniphilum.
OX   NCBI_TaxID=2382159 {ECO:0000313|EMBL:RNC64244.1, ECO:0000313|Proteomes:UP000272792};
RN   [1] {ECO:0000313|EMBL:RNC64244.1, ECO:0000313|Proteomes:UP000272792}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=X52 {ECO:0000313|EMBL:RNC64244.1,
RC   ECO:0000313|Proteomes:UP000272792};
RA   Hivarkar S., Lanjekar V.B., Dhakephalkar P.K., Dagar S.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the multi antimicrobial extrusion (MATE) (TC
CC       2.A.66.1) family. MepA subfamily. {ECO:0000256|ARBA:ARBA00008417}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNC64244.1}.
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DR   EMBL; RDSD01000016; RNC64244.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M8EHZ8; -.
DR   OrthoDB; 9811110at2; -.
DR   Proteomes; UP000272792; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0042910; F:xenobiotic transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   CDD; cd13143; MATE_MepA_like; 1.
DR   InterPro; IPR002528; MATE_fam.
DR   InterPro; IPR045070; MATE_MepA-like.
DR   InterPro; IPR048279; MdtK-like.
DR   NCBIfam; TIGR00797; matE; 1.
DR   PANTHER; PTHR43823:SF3; MULTIDRUG EXPORT PROTEIN MEPA; 1.
DR   PANTHER; PTHR43823; SPORULATION PROTEIN YKVU; 1.
DR   Pfam; PF01554; MatE; 2.
DR   PIRSF; PIRSF006603; DinF; 1.
PE   3: Inferred from homology;
KW   Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|ARBA:ARBA00022448}.
SQ   SEQUENCE   460 AA;  50675 MW;  7391AB7733C61CE5 CRC64;
     MQSKREQDFQ TKKISKLVWD YALPGIVGTL VTAMYNVIGR IFIGQGVGAL AISGLAITFP
     VMNLTASLGM LVGAGGAARI SISLGKQDRL TAEKILGNSL LITVILNAVF ITLILIYLDP
     LLRAFGASDL TLPYARDYLQ IVLLGNVFVS LCYNFNAMMR SSGYPKKAMI TMLIGAVFNI
     ILTPLFLYLF NLGIKGVAWA TVISMFIGML FVMDHFTRES SLIRLRWKNV RLDKKIVAAI
     LSIGISPFSM QVAASGVAVL LNTSLLRHGG DLAVGAYGII NTVIMTFVMI IMGLNQGTQP
     IIGYNYGARN FTRVKETLYY SLKVATALTT FTFIVGQFFP RLFASAFTND PELLSITEKG
     IRITIAAFPL VGIQIVASSF FQSLGYAAKS IIQSLSRQLI FLIPFIILFP RLWGLDGIWT
     AMPVADTLSA ILSIYLLIIQ LRLLNRMEEE EQRRLRSAPF
//