ID A0A3M8F752_9ACTN Unreviewed; 422 AA.
AC A0A3M8F752;
DT 08-MAY-2019, integrated into UniProtKB/TrEMBL.
DT 08-MAY-2019, sequence version 1.
DT 28-JUN-2023, entry version 15.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:RNC74017.1};
DE EC=4.2.1.75 {ECO:0000313|EMBL:RNC74017.1};
GN ORFNames=DC095_014355 {ECO:0000313|EMBL:RNC74017.1}, SFRA_004625
GN {ECO:0000313|EMBL:RKM97846.1};
OS Streptomyces xinghaiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1038928 {ECO:0000313|EMBL:RNC74017.1, ECO:0000313|Proteomes:UP000245280};
RN [1] {ECO:0000313|EMBL:RKM97846.1, ECO:0000313|Proteomes:UP000028058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19609 {ECO:0000313|EMBL:RKM97846.1,
RC ECO:0000313|Proteomes:UP000028058};
RX PubMed=25477406;
RA Bekker O.B., Klimina K.M., Vatlin A.A., Zakharevich N.V., Kasianov A.S.,
RA Danilenko V.N.;
RT "Draft Genome Sequence of Streptomyces fradiae ATCC 19609, a Strain Highly
RT Sensitive to Antibiotics.";
RL Genome Announc. 2:0-0(2014).
RN [2] {ECO:0000313|EMBL:RKM97846.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 19609 {ECO:0000313|EMBL:RKM97846.1};
RA Danilenko V.N., Bekker O.B., Vatlin A.;
RT "Genome sequencing of Streptomyces fradiae ATCC 19609.";
RL Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:RNC74017.1, ECO:0000313|Proteomes:UP000245280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OlgR {ECO:0000313|EMBL:RNC74017.1,
RC ECO:0000313|Proteomes:UP000245280};
RA Danilenko V.N., Bekker O.B., Vatlin A.;
RT "Genome sequencing of Streptomyces xinghaiensis (fradiae) OlgR.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNC74017.1}.
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DR EMBL; JNAD02000002; RKM97846.1; -; Genomic_DNA.
DR EMBL; QFBD02000005; RNC74017.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8F752; -.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000028058; Unassembled WGS sequence.
DR Proteomes; UP000245280; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Lyase {ECO:0000313|EMBL:RNC74017.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000028058}.
FT DOMAIN 315..408
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 315..408
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 422 AA; 44090 MW; 60C1CFDAB4DDB366 CRC64;
MQDPTPQPSP PAPGRPGGPE PDAPGPAPTA AGAAPSQGPP GSPPAPGPLA GFTVGITAAR
RAEELGALLE RRGATVLHAP AIRIVPLPDD TELLAATKDL IADAPDIVVA TTAIGFRGWI
EAADGWGLGE ELTARLRGVE LLARGPKVRG AIRAAGLTET WSPASESMAE VLDRLLAEGV
ADRRLAVQLH GEPLPGFVEA LREAGAEVVG VPVYRWLPPE DIGPVDRLLD ATVARSLDAV
TFTSAPAAAG LLERARDRGL LEPLLEALRH DVLAACVGPV TAMPLLEHGI QAVRPERFRL
GPLVQLLCRE LPARAGVLPV AGHRLDIRGH AALVDGELRA VPPAGMALLR ALARRPGWVV
SRAELLRALP GAGRDEHAVE TAMARLRTAL GTPKLIQTVV KRGYRLALDT ASDSKYAENE
GP
//
