ID A0A3M8G2I6_9BACT Unreviewed; 889 AA.
AC A0A3M8G2I6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 16.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:RNC84555.1};
GN ORFNames=ED557_06135 {ECO:0000313|EMBL:RNC84555.1};
OS Balneola sp.
OC Bacteria; Balneolota; Balneolia; Balneolales; Balneolaceae; Balneola.
OX NCBI_TaxID=2024824 {ECO:0000313|EMBL:RNC84555.1, ECO:0000313|Proteomes:UP000280416};
RN [1] {ECO:0000313|EMBL:RNC84555.1, ECO:0000313|Proteomes:UP000280416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bin6 {ECO:0000313|EMBL:RNC84555.1};
RA Zheng Q., Wang Y., Jiao N.;
RT "Metagenomics and metaproteomics analyze the interactions between
RT Synechococcus and associated heterotrophic bacteria in one oligotrophic
RT Synechococcus culture.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNC84555.1}.
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DR EMBL; RHLJ01000002; RNC84555.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8G2I6; -.
DR Proteomes; UP000280416; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000280416}.
FT DOMAIN 694..710
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 620..627
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 889 AA; 100158 MW; 4FE240EA1BFCC20C CRC64;
MTARKQTPLM RQYNEIKEEH PGTILLFRVG DFYETFSDDA ILVSKELGIT LTKRNNGGDQ
TPLAGFPFHA LDTYLPKLVK KGYKVAVCEQ TEAPEEAKKA GRKIVEREVT EITTPGVTMS
EKLLEHKRNN YIMSLFWTKD SLGVAFSDIS TGEFGLSEIR EQELDSLLAG IQPAEILVQT
KKKNTLNGSF TPFNITYIDD WVYEGDYGYK LLTEHFNTHS LKGFGVEELN TAQVAAGSLL
HYMQETQKAY LRHLRRLYAY ESNEFMSLDP STKRNLELTA SLQEGGVEGT LISILDNTCT
AMGGRLLRKW IMRPLKLLKP IHQRLDAVEE LFKAHTIRST LREELEQVGD LERLISRICV
GRSNARDLVQ VKLSLLQLPR IKSQFAAIDN PLLQDIGKRM RFLIDLQDRI SQTIADEPPA
GIRDGNMIRE GFNAELDELR DIAKNGKSYI AKIKDQLSAE TGITSLKIGY NKVFGYYIEV
TNAHKDKVPE TFIRKQTLVN AERYITPELK EIEEKILSAE DRSKSLEFEL FEEIRLFTAE
FADDIQQIAY ALSQLDCIQS FAEVAFRNNY AKPEVRDSEK IDIKKGRHPV VEQSLPLGEP
FIPNDIELDN SEQQIMIITG PNMAGKSIIL RQTGLIVLLA QIGSFVPAES AHIGLVDKIF
TRVGASDNLA AGESTFLVEM NEAANILNNA TPRSLILLDE VGRGTSTFDG LSIAWSLAEY
LHNQASVAAK TLFATHYHEL NELEQMYDRV KNFNVQVKEH DGKVIFLRKL IRGGADHSYG
IQVANMAGLP EVVINRAKEI LGNLENHSLD ITNKNGSIEQ KATEGKKAAQ HLSQNLEKQE
SIEQMSLFTT HIDPRLETLM NKLEATDPNR MTPIEALMLV NELKRVLGN
//
