ID A0A3M8HFN9_9BACI Unreviewed; 612 AA.
AC A0A3M8HFN9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:RND01220.1};
GN ORFNames=EC501_02300 {ECO:0000313|EMBL:RND01220.1};
OS Lysinibacillus halotolerans.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Lysinibacillus.
OX NCBI_TaxID=1368476 {ECO:0000313|EMBL:RND01220.1, ECO:0000313|Proteomes:UP000279909};
RN [1] {ECO:0000313|EMBL:RND01220.1, ECO:0000313|Proteomes:UP000279909}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCCC 1A12703 {ECO:0000313|EMBL:RND01220.1,
RC ECO:0000313|Proteomes:UP000279909};
RX PubMed=24814335; DOI=10.1099/ijs.0.061465-0;
RA Kong D., Wang Y., Zhao B., Li Y., Song J., Zhai Y., Zhang C., Wang H.,
RA Chen X., Zhao B., Ruan Z.;
RT "Lysinibacillus halotolerans sp. nov., isolated from saline-alkaline
RT soil.";
RL Int. J. Syst. Evol. Microbiol. 64:2593-2598(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RND01220.1}.
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DR EMBL; RHLQ01000003; RND01220.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8HFN9; -.
DR OrthoDB; 570124at2; -.
DR Proteomes; UP000279909; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000279909};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 12..391
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 402..483
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02254"
SQ SEQUENCE 612 AA; 67435 MW; 5E9A587B390238C7 CRC64;
MLDNLLIQIV AIVGLGILSQ WVAWRFKLPA IVIMSLVGLL VGPLLGLFNP QKSFGEVFNP
TIALAVAVVL FEGSLGLDLR EIKGFRQSIF RISTLGAFIA WIIGSLAAHF IAGLSIDVAF
VMGGLFIVTG PTMILPLLRQ AKLKERPATI LKWEAIIVDP FGALVALFAL EMVLYMNGMI
SEGSLLLFFV ASIFSAIIGA GVGFLLGRLL EHGFIPEFLK SPVVLVSVLL VFVLSEEIIH
ETGILAVTAM GIVMANMHLT SLRELLHFKE NVSVLLISTL FIMLTSSLSI ETLLDILNWR
MLLFVLAMLF VVRPVSVWLS TIGVGLPKRE RLLLGWIAPR GIIALTVSGF FASVLTESGF
EDADIITALT LALVFATVLA HGLSISWLAK KLNLQCTDEM GVTIVGGSPF TAVLGEAIQS
FQKPVLIIDR SWSALSEARQ LGIKTEVGDI LSEYTEFHVD LTPYEILVAA TEEDAYNALI
CQRFVPELGR EHIFQTPIPT GDLSDYSQSI VGKTLFDEDY DIYTLNRLIN EGYMIRKTQL
TEQYTFERYL DGDGHKTIPL FAVDKDHHLI FFTKGIKRSF DVGTTIVSLT SPTRRMEKAM
EKANQTEIPP KD
//
