ID   A0A3M8LBF1_9MICO        Unreviewed;      1037 AA.
AC   A0A3M8LBF1;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Alpha-mannosidase {ECO:0000313|EMBL:RNE62655.1};
GN   ORFNames=EEJ31_07355 {ECO:0000313|EMBL:RNE62655.1};
OS   Cryobacterium tepidiphilum.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Cryobacterium.
OX   NCBI_TaxID=2486026 {ECO:0000313|EMBL:RNE62655.1, ECO:0000313|Proteomes:UP000279859};
RN   [1] {ECO:0000313|EMBL:RNE62655.1, ECO:0000313|Proteomes:UP000279859}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NEAU-85 {ECO:0000313|EMBL:RNE62655.1,
RC   ECO:0000313|Proteomes:UP000279859};
RA   Wang Y.;
RT   "Cryobacterium sp. nov., isolated from rhizosphere soil of lettuce.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
CC       {ECO:0000256|ARBA:ARBA00009792}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNE62655.1}.
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DR   EMBL; RDSR01000009; RNE62655.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M8LBF1; -.
DR   OrthoDB; 9772207at2; -.
DR   Proteomes; UP000279859; Unassembled WGS sequence.
DR   GO; GO:0004559; F:alpha-mannosidase activity; IEA:InterPro.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006013; P:mannose metabolic process; IEA:InterPro.
DR   CDD; cd10789; GH38N_AMII_ER_cytosolic; 1.
DR   Gene3D; 2.60.40.2220; -; 1.
DR   Gene3D; 3.20.110.10; Glycoside hydrolase 38, N terminal domain; 1.
DR   Gene3D; 1.20.1270.50; Glycoside hydrolase family 38, central domain; 1.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR041147; GH38_C.
DR   InterPro; IPR011330; Glyco_hydro/deAcase_b/a-brl.
DR   InterPro; IPR011682; Glyco_hydro_38_C.
DR   InterPro; IPR015341; Glyco_hydro_38_cen.
DR   InterPro; IPR037094; Glyco_hydro_38_cen_sf.
DR   InterPro; IPR000602; Glyco_hydro_38_N.
DR   InterPro; IPR027291; Glyco_hydro_38_N_sf.
DR   InterPro; IPR028995; Glyco_hydro_57/38_cen_sf.
DR   PANTHER; PTHR46017; ALPHA-MANNOSIDASE 2C1; 1.
DR   PANTHER; PTHR46017:SF1; ALPHA-MANNOSIDASE 2C1; 1.
DR   Pfam; PF09261; Alpha-mann_mid; 1.
DR   Pfam; PF17677; Glyco_hydro38C2; 1.
DR   Pfam; PF07748; Glyco_hydro_38C; 1.
DR   Pfam; PF01074; Glyco_hydro_38N; 1.
DR   SMART; SM00872; Alpha-mann_mid; 1.
DR   SUPFAM; SSF88688; Families 57/38 glycoside transferase middle domain; 1.
DR   SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR   SUPFAM; SSF88713; Glycoside hydrolase/deacetylase; 1.
PE   3: Inferred from homology;
KW   Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000279859}.
FT   DOMAIN          521..599
FT                   /note="Glycoside hydrolase family 38 central"
FT                   /evidence="ECO:0000259|SMART:SM00872"
SQ   SEQUENCE   1037 AA;  112257 MW;  807DC4B59A09A2AE CRC64;
     MHDDSARVQA RLDRFVRERM PRALYRAASP LTIEAWEAPG EPVPFAEAVR QDFRPFAAGT
     DWGRAWGTTW FHLTGVVPDG WAAAASTGEV ALEAVVDLGF TAEVPGFQVE GTAYTADGAI
     VKAVESFNRW LPLSPGGPID LYIEAASNPD IAQAWTFTPT PDGDLATARP GHRYTFRQAD
     VALRDIPVWE LAQDIWTLDG LLRELPLIDA RRADLVRALD RCLDAVDPDD VAGTASAGRA
     ELAGVLASPA TASAHRLHAV GHAHIDSAWL WPTRETVRKV ARTFSNVLAL VEENPDFVFA
     ASSAQQYAWL KEHYPELFER VRAAVAAGSI VPVGGMWVES DTNLPGGEAL VRQFVAGKRF
     FLEEFGVEPE EVWLPDSFGY SGSVPQIAAA AGMRWFLTQK LSWNDTNVFP HHTFRWEGLD
     GTRIFTHFPP VADYNAQLSG AELARAARVF AEKGHANTSL IPFGWGDGGG GPTREMIAAA
     RRTASLEGSP SVTLSSPRRF FEAAEAEYPA PPVWSGELYL EFHRGTYTSQ ARTKRGNRRS
     EHLLREAEVW AATASVRGLA DYPYDALETA WHTVLLQQFH DILPGSSIAW VHREAERNYA
     ALAVTLEGLI ESALRALAGS GAATLVANAG PYALEEVPAL GGAPGDRSPG EGSHVDLPEA
     AGGRFAIPHA AGAASATRVG ESIRLRNDRV LVVIDADGLF TSVMDLANAR ELLAEGARGN
     LPQLHRDVPA KWDAWDLDAN YRRTVTDLTA ADSVAIVSDG SDGYSAHVRV ERSVGASRIT
     QDITLAPGRA AIDIGVAIDW HERQKLLKLA FPLDVHADRA ASEIQFGHVF RPTHTNTSWD
     AARFETVAHR WVHVGEPGYG VAIANDASYG HDITRTTDAA GHPATTVRLS LLRAPLYPDP
     DADQGEHRFR VALGVGAGIP DAVAEGYRLN LPLRTLTGVA DPSIEPLFSI DNPAVVIEAV
     KLAEDRSGDV VVRLYEAHGS RALATLIRSF DAADATETDL LERPLGRPRA VVGAAGAETT
     LELRPFQLVT LRFARRS
//