ID A0A3M8RI19_9PROT Unreviewed; 836 AA.
AC A0A3M8RI19;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:RNF67965.1};
GN ORFNames=EC580_03605 {ECO:0000313|EMBL:RNF67965.1};
OS Acidithiobacillus sulfuriphilus.
OC Bacteria; Pseudomonadota; Acidithiobacillia; Acidithiobacillales;
OC Acidithiobacillaceae; Acidithiobacillus.
OX NCBI_TaxID=1867749 {ECO:0000313|EMBL:RNF67965.1, ECO:0000313|Proteomes:UP000271650};
RN [1] {ECO:0000313|EMBL:RNF67965.1, ECO:0000313|Proteomes:UP000271650}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CJ-2 {ECO:0000313|EMBL:RNF67965.1,
RC ECO:0000313|Proteomes:UP000271650};
RA Falagan C., Moya-Beltran A., Quatrini R., Johnson D.B.;
RT "Acidithiobacillus sulfuriphilus sp. nov.: an extremely acidophilic sulfur-
RT oxidizing chemolithotroph isolated from a neutral pH environment.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNF67965.1}.
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DR EMBL; RIZI01000128; RNF67965.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M8RI19; -.
DR OrthoDB; 5287141at2; -.
DR Proteomes; UP000271650; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000271650}.
FT DOMAIN 672..688
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 598..605
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 836 AA; 92042 MW; EDBB12D6268F8FC8 CRC64;
MMQQYLRLKA ECPEALLLYR MGDFYELFFA DAEKAAQLLD ITLTSRGVSA GQPIPMAGVP
VQSLDTYLAR LVKLGQSVAI CEQVGDPANG RGPVERAIVR VITPGTITDG ELLDARNEPL
LLAVWGEGQR WGLAWLDAAG GRLTVREVGG PALADEIERL QPAEILWPEG EVVPAAGRSR
ARFLAKTAFQ EARTHATLLR HFGARLPSFG CADLPLALRA AGAILAYAET QLHRPLTQVR
RIHPQRPEEE LHVDTTALRA LEVLDSLQGN GPSLYGVLQH TQSPMGARLL RRWLLRPLRQ
GRELSKRHDI VNTLIAQGFT ALRKAMKGLP DGERLLTRIA LKSASPRDMA LLRQVLQHLP
ALREALEALP HPALCEALAK IPSFTRLYER LCRALVDNPP VTLRDGGVLR AGFDAELDRL
NSLSHDLQGV LRDLEQRERA RTGITQLKIQ FNRVHGFYIE VGRSHQGPLP ADYRRRQTLK
NAERYINDEL KAIEDQALSA QSLALARERL LFTQLLDEVG ADLPALQEAM ETVAWLDCLS
TLAERAVTLD YCAPVFRNEG ILHIQDGRHP VVEAQLGSAF VPNDLHCNES RRMLLITGPN
MGGKSTYMRQ NALIVLMAHI GSRVPAREAI IGPIDQIFTR IGAADDLAGG RSTFMVEMSE
TARILHLATA ESLVILDEIG RGTSTYDGLA MAWASAEALI ARGAYTLFAT HYFELTEISL
PGLSNVHLDA LTQGEGVIFL HRVEDGPASQ SYGLAVARLA GIPEAVIGRA RERLLELEDP
ARENLRAAEH PAQLALFQPQ HPALALLAAT DPDQLSPKKA LDLIYQLHSL LHQELN
//
