ID A0A3M8SRE0_9GAMM Unreviewed; 3244 AA.
AC A0A3M8SRE0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:RNF83333.1};
GN ORFNames=EER27_12640 {ECO:0000313|EMBL:RNF83333.1};
OS Lysobacter psychrotolerans.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC Xanthomonadaceae; Lysobacter.
OX NCBI_TaxID=1327343 {ECO:0000313|EMBL:RNF83333.1, ECO:0000313|Proteomes:UP000267049};
RN [1] {ECO:0000313|EMBL:RNF83333.1, ECO:0000313|Proteomes:UP000267049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZS60 {ECO:0000313|EMBL:RNF83333.1,
RC ECO:0000313|Proteomes:UP000267049};
RA Luo Y., Sheng H.;
RT "Lysobacter cryohumiis sp. nov., isolated from soil in the Tianshan
RT Mountains, Xinjiang, China.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNF83333.1}.
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DR EMBL; RIBS01000005; RNF83333.1; -; Genomic_DNA.
DR OrthoDB; 9757559at2; -.
DR Proteomes; UP000267049; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd05930; A_NRPS; 2.
DR CDD; cd17651; A_NRPS_VisG_like; 1.
DR CDD; cd19531; LCL_NRPS-like; 2.
DR CDD; cd05235; SDR_e1; 1.
DR Gene3D; 3.30.300.30; -; 3.
DR Gene3D; 3.40.50.980; -; 6.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR010080; Thioester_reductase-like_dom.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 3.
DR NCBIfam; TIGR01746; Thioester-redct; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 3.
DR Pfam; PF13193; AMP-binding_C; 3.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF00550; PP-binding; 3.
DR SMART; SM00823; PKS_PP; 3.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 3.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00455; AMP_BINDING; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000267049}.
FT DOMAIN 620..695
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1697..1772
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2761..2836
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 16..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..60
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3244 AA; 354516 MW; EECBA357C7D09A02 CRC64;
MIARRVGAAI ALSSDFPSRK RTGRNPTPRG LRASSHPSWI RCAKHSDGDS SGRDEMNHTS
DAHGMTTVEI QAHDALATDL TEQPSLLAAD ERTLLLESWN QTESRYPSEL CLHQLMERQA
QRSPDAIALV HEDQSLSYAQ LNAQANRLAH HLIELGVKPD DRVALCVERG IAMVVGLLAI
LKAGGAYVPF DPTYSSARLA QVLADAAPVL LLSDAAGRNA LGEAALESMI VLDLLIDLPS
WSGQPDCDPQ VSGLASHHLA YVIYTSGSTG TPKGVMVEHR NVVHLAHTHI ARFQISPQSR
VVQFASLGFD ASVFELVMAL TSGAALYLPA PADRQTGPAL MAYLTRHAIT HALLPPAFLQ
GHTYTLTTQP VLILGGEAPS PALVRTLASQ ATVINAYGPT EITVCATAWT SPAAVDELDC
VPIGRPIANT RIYLLDDQAQ PVPLGAVGEL YIGGAGVARG YLNRPDLTAE RFVTDPFSPH
PGARMYRTGD LARYLPDGNL VFLGRNDHQV KLRGFRIELG EIEARLAEHP AVRESVVLAR
EDVPGEPRLV AYIVPTDDAA ARDDLAGVLR THLGTRLPDY MLPAAFVALD ALPLTPNGKL
DRTALPAPDG EAFVRRAFEA PQGEIETVLA QHWQALLGIE RVGRHDHFFE MGGHSLVAVR
LLSRVGEAFD IALPLATLFA RPTLAELATA IASRCTDARV LALPPIVPVS REDALPLSFA
QQRLWFLAQL DGVSTSYNMP LVLRLHGPLD TAALRRSLDR LFARHEGLRT VFRAVDGEPQ
VALLAADAGL PLIEHDLRDA TDVATALAQL TAKDAQTSFD LAHGPLIRAR LIRLADREHV
FVITQHHIVC DGWSMSLLAR ELSALYTAFC QHQPDPLPPL AVQYPDYAAW EQTWLVGERL
QPQADFWRRT LAEAPTVLAL PTDRPRPPQQ SFAAAALPVQ LDVALTQRLK RLSQRHGTTL
FMTLMAAWAT VLARLSGQDD LVIGTPSANR SRREIEPLIG FFVNALPLRI DLSGQPSVAE
LLTRVRDVAL AAQEHQDLPF EQVVEIARPS RRLDHTPLFQ VLFAWQSNEE GLFDFPGLRV
EPQMPFDAIR FDLELHLHET EETVVGTLGY ATALFDAATM ERHRGYLIAV LDAMAAEVQP
PVMQIEMLAS AERTSLLESL NQTDAVYPSE LCIHQLFEQQ VQRCPDAIAL VHEDQSLSYA
QLNAQANRLA HHLIDVGVRP DDRVALCVER SFAMVIGLLA VLKAGAAYVP LDPTYPTERL
AQVLGDAAPA IVLSDAVGRR ALGETATARQ QTLDLDAFAS LSADSSATHS NPQPLGLTPE
HLAYVIYTSG STGVPKGVAM SHGPLVNLIG WQISHAGPAQ RTLQFAALGF DVAFQEIFCA
LCAGGSLVLI DSQVRLNFAK LIQTICTQNI QRIHLPYIAA QSLAEVIDDI GDAQMDQLRR
GLRDVIVAGE QLRLTPQIKR FFQKLPDCRL HNHYGPTETH VVTAFVLGDG IQDAPTHVPI
GRPIANSRAY LLDGHGQPVP FGAAGELHIG GTGIARGYLN RPELTAERFL TDPFSTHPDA
RMYRTGDLAR YLPDGNLEFL GRNDHQVKLR GFRIELGEIE AQLSDHPSVL ECAVLAREHV
PGEPRLVAYV VQVGGVASRD DLALVLRSHL SMRLPEYMVP AAFVMLDVLP ITPNGKLDRN
ALPVPDGDAY VRRTYDPPQG ETETILAQLW QELLGVERVG RHDHFFELGG HSLVAVRLLS
RVTRTFSIEL PLAALFAQPI LAELATTVAA HLAHGSAAAL QAISSIPRDG MLPLSFAQQR
LWFLAQLDGA SANYHVPLAL RLRGALDASV LRRSLDRLFA RHEGLRTVFV SVNGQPHVKL
LPADASLPLI EHDVRGIAHA SPVLARMIAE EIGTTFDLSQ GPLIRASLIR LDEQEHVFLL
TMHHIVSDGW SLGVLVDELS ALYAAYSQER PDPLSPLAIQ YPDYAAWQRQ WLAGERLQVQ
ADYWRRRLAD APTLLALPVD RPRPPQQSFD AAFLPVMLDA ELVQGVKRLG QQHGTTVFMT
LLAAWSVVLS RLAGQDDLVI GTPTAGRSRH EVEPLIGFFV NTLPLRIDLS DGPRVTDLLA
RVRQTALDAQ THQDLPFEQV VEALKLPRRL DHTPLFQVLF AWQSNDEGVL DLPGLQVEPE
PYTFEWVKFD MELFFSEKDG TIQGGFNYAT ALFDATTVER HRDYLVAVLQ AMVADVQQPV
AQIDLLAADE RTLLLESWNQ TELAYPTQLC LHGLFEQQVQ RCPDATALVH DDGSLTYGQL
NAQANRLAHY LVELGVKPDD RIALCAERSF AMVVGLLAIL KAGGAYVPFD PAYSSARLTQ
ILTDAAPVLV LSDAAGREAM GEAALESLNV VDLLANHPAW SEHPDSDPQV LGLTSHHIAY
VIYTSGSTGT PKGVMVEHRN VVHLAFAQMA QFQISPQSRV AQFASLGFDA SVFEVVMALC
SGASLFLPTQ AERQTAPAFM AYMARHAITH TILPPAFLHG HADLPQLTTR PMVMLGGEAP
SPSLVRTLSE RATVINAYGP TEITVCATAW TSPRKMGERD SIPIGRPIAN TRLYLLDDHG
QPVPLGAVGE LYIGGAGVAR GYLNRPDLTA ERFLADPFSP HPDARMYRSG DLARYLPDGN
LVFLGRNDHQ VKLRGFRIEL GEIEARLAEH SAVRECVVLA REDVSGEPRL VAYVVPADEA
AARDDLAGVL RTHLAPRLPD YMIPAAFVAL DVLPLSTHGK LDRKALPAPD GDAFVRRAFE
APRGEIETTL ARLWQALLGI ERVGRNDHFF DLGGHSLIAV HLIASVRQAL NVDAAVRDIF
RYPVLKDMAQ LLLPASASLP RVLDLNAELQ LDPTINAAQP FLPQAKPKHV LLTGASGFLG
VFLLSSLLKK TDAIVHCLIR CASAEKGRSR LEASLASLGL GDYDRNRVVI VPGDLSRPLL
GLSPARFADM AELMDVIYHN GAWVNSLHTY ETLKASNVLG TQEVLRLASS GKLKHVHYIS
TMSTIPPIDA LQEIVSTEEE LFECWQGLAS GYAQSKWVAE KILRIGGSRG IPFTVYRPTH
ISGSTRDGAS NPIDTWSLFM DACLQHGCVP DVDASLNSLP VDYMSECIVD LSLRDDVIGK
SLNLMNPRTF MLKQLTDGML SMDASMKTVS YREWLDICAE STSTKNIASI MPADLATEPG
VSTTQGEVKL GNAVEQLMSE GSRCPSITDE LLQKYVGWRI RNRAVPPRAA SDRSPPTHRE
ICDA
//
