ID   A0A3M9XZU0_9PEZI        Unreviewed;      1201 AA.
AC   A0A3M9XZU0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE            EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN   ORFNames=D7B24_001363 {ECO:0000313|EMBL:RNJ53787.1};
OS   Verticillium nonalfalfae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ53787.1, ECO:0000313|Proteomes:UP000267145};
RN   [1] {ECO:0000313|EMBL:RNJ53787.1, ECO:0000313|Proteomes:UP000267145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ53787.1,
RC   ECO:0000313|Proteomes:UP000267145};
RA   Stajich J.E., Kasson M.T.;
RT   "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNJ53787.1}.
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DR   EMBL; RBVV01000127; RNJ53787.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3M9XZU0; -.
DR   STRING; 1051616.A0A3M9XZU0; -.
DR   OrthoDB; 1386at2759; -.
DR   Proteomes; UP000267145; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   4: Predicted;
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          826..1201
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          1..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          682..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..48
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1169
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1201 AA;  135599 MW;  CE16EA4CD0EED6E9 CRC64;
     MHSTFTGNSR RTRNVNLSGQ NQNPFANVWS PSASSGASKT VSNAQAERQQ RQLERDRLKA
     ARNIQRTWRS HHVRRQCRDV WRQAFDDIYR ADNPNTAVQR VHAALPLLLA AFQSNRPEDV
     HRLASIARDV MSQHVRSLVP ASENESSREQ EDHRLRRLSE ITVEALGATT METLLQPESK
     LLVDLLAYLV AGQPQSVMQV LSQYFRLLAT LVRASASDQQ QLEKVLALVL APLNEPPQYV
     SAEDVRPFTT RAYDAFAFDF LAVGDIAPLQ QENNLIAQRI DIDKLSGAII EAYSGPRAAA
     ATPDSLLWLL AYFIDIHQTQ KSTSHHLGSL HAMHLQLSSL ASQIRFRLPL ASNGTSRNTE
     RANDGTESML RPLPPYVSTK LTSCVDRAGI TDILSDLAST LAPESNATSA SPNNKSFQGA
     SLLAGYIVTL LRCFPTFADD IRMRLFLGDI PSTGGNIPVI KYLWKTMSQT SLFERICHDK
     GSAHAVGSIP SLIKRYLSKS GTQEYSALEE QEWRLTLLFL ELYTFILRLS DDDDFFSGIW
     PRIIENDEPQ TRLRACSLTL EDIKNLTLFL KNLAFALHYY TNEILQDLAP SLASSNGLDS
     FFGFVEGQKA STKGRRTSLG PKGLSFDKPD LAGLRAIVTS TLRMLYERDS RRPFLPRDHW
     LMTSKFDMEK FASSVVREHD RQQEELANLS EDEDQDEEDD MDDDVEMENG VHTFAGQRLS
     QHAQIENIRA RQRRAQKARM LSVIGPKLEI LRHMPFVIPF DARVHIFRQF IYLDQQKRRQ
     GMDAEQWRMT MINNPLLPQR GLTGRHRGSI KRGQEFDDAF EQFYELGESL KEPVQIQFID
     SFGDVEAGID GGGVAKEFLL SAINQVFMNQ SEDRYFVENN QKLWYPNPII FDKFREEAEE
     MGLPEAEKKD ILTGLSQRYE FLGRLVGKCM YEDILIDVNF AGFFLLKWAA SGLTGEESYR
     GNVNDLRDLD ASLYQGLVHL KNLPADEVES LSLDFTVDDQ ISADGETVRS LTRELIPGRG
     STPVTKDNRL LYISYMARHR LVVQPAQQTM AFLRGLRAIV APTWLSMFNQ TELQRLVGGD
     SSEISIDDLR DNTNYSGLYV IGDDGEEHPT IQLFWKVVRG FTDAQRRDLL KYVTSTPRAP
     LLGFGSLNPL FSIRDGGTDE ARLPSASTCV NLLKLPRYTD EETLRRKLVL AISSGAGFDL
     S
//