ID   A0A3M9Y195_9PEZI        Unreviewed;      1616 AA.
AC   A0A3M9Y195;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   08-NOV-2023, entry version 16.
DE   SubName: Full=Tuberous sclerosis 2-like protein {ECO:0000313|EMBL:RNJ54263.1};
GN   Name=TSC2 {ECO:0000313|EMBL:RNJ54263.1};
GN   ORFNames=D7B24_000721 {ECO:0000313|EMBL:RNJ54263.1};
OS   Verticillium nonalfalfae.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX   NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ54263.1, ECO:0000313|Proteomes:UP000267145};
RN   [1] {ECO:0000313|EMBL:RNJ54263.1, ECO:0000313|Proteomes:UP000267145}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ54263.1,
RC   ECO:0000313|Proteomes:UP000267145};
RA   Stajich J.E., Kasson M.T.;
RT   "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNJ54263.1}.
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DR   EMBL; RBVV01000110; RNJ54263.1; -; Genomic_DNA.
DR   STRING; 1051616.A0A3M9Y195; -.
DR   OrthoDB; 20915at2759; -.
DR   Proteomes; UP000267145; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR035974; Rap/Ran-GAP_sf.
DR   InterPro; IPR000331; Rap/Ran_GAP_dom.
DR   InterPro; IPR018515; Tuberin-type_domain.
DR   InterPro; IPR027107; Tuberin/Ral-act_asu.
DR   InterPro; IPR024584; Tuberin_N.
DR   PANTHER; PTHR10063; TUBERIN; 1.
DR   PANTHER; PTHR10063:SF0; TUBERIN; 1.
DR   Pfam; PF11864; DUF3384; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   Pfam; PF03542; Tuberin; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
PE   4: Predicted;
KW   GTPase activation {ECO:0000256|ARBA:ARBA00022468}.
FT   DOMAIN          1254..1487
FT                   /note="Rap-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50085"
FT   REGION          632..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1489..1560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1574..1602
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1495..1528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1546..1560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1616 AA;  178523 MW;  7E6ED9AD744B21AD CRC64;
     MSRSPGDVAS SPDSSRAGGL ANVFKGLTGA KLTKSPPPIA QSIFPPAISP MVDRPTGATP
     VAADVLSRNH MEAFEQLKNG SPNERAAAAD SLRYAISEYP LSPVLDIWYA AKDLIDAGKA
     SAARIAGWEL LAECVKHKSS TDLERKEFFQ TLTAPANPED FHLQLASLVD LTNHGRDLSG
     FDYDVIPLLR KWLREAYQAV KVARKHASRD AKRNPKLRVS VAGEEKNLQQ LFTFIVEVTK
     FSSNVADETA LAGLVNALVA ICLNTIVEDD LRACIGVIDA IVTFGSLPSG SFRECVLVLG
     SIFCLVPNLH KPAWHTLSII LKSHNGHATV RVLLDLLRDL PADGNSKGKD TRDIRGALAV
     LEKLVAKSTE KGYPTVPFTL LMNGLVATVQ CTPSARVHCA VLKLLNSLFS DSDGKLHHMI
     AEENWTTALS IATECSKKAT QATSGDNDAT KTETESDRPY EAIRRELLRM IARLESLMTS
     KNGSFVPRPV VIQFFMDVHT LIPDSTAVVV LDYFQEFRCC SPSDLEWEDN LALVRRGFFG
     NRQRSSHVRL LALRSITDAY EMMDLVGEEM EEDCIATLVK DLLSDVSAET DVAVLDALVS
     LMVDVAIASD QELFNFIIST LKSLVSSDRL EPPASQALSP GAPPTLERSP FESESSKSDI
     VTQGFVRLFM RCMNANGLKS AKLFDILVSI ARGSHNQIDA RLTAMKLLFR LRADWASSIF
     LTVETEAEGL AASLYRTEAS LARKQAGDAT LSARASRAEH GGPVRSARAI SFSHAGTQDR
     SYPIRSVSGA NKTVPRQKHL WSLPDQDALP EKPSTIASSV LVSYSEKVSQ YLSNSEEPKA
     EEDSTHHVAL NVTAWLSTIN TIFENGCDWE VFSMILVHLP SQLSNHAMFR GALTEMQRLR
     RVVCEQIRLN AFQEPPTYTG LRRADVAICL FHSLTMILSY HEHFLKDQED EIVRAFVHGI
     STWERCAKYC IHALSICCHE LPLSTSKCLV QMLQKMAQII TQPHVAMHIL EFLAGLSRLP
     ALYVNFREEE YRIVFGICIR YLQYIRDKQQ NHRALELSPT TVDGNSASTD DLPQYVYSLA
     HHVITFWFLA LRLPDRSNHV GWIAKNLFAN VESGQGLEEQ AMVTIDFMQR VAYADANESS
     CDPLFTKERF GEILTRRWLI GNSIVTIEQA TATGWAQITK RQPSGTSSYI VRENFRPPPA
     HQTMQGTEVV RASDHSNNVL PSHLMVQLMT SIPQTSESLR PIPLPDDDAV QRAVRVFDRN
     STVDGHKVGV IYIGEGQTDE VEILSNVSGS SDYVEFLNGL GTLTKLKGST FNTQGLDRDY
     DSDGQYTFCW RDRVTEMVFH VITQMPTNLE RDPQCILKKR HIGNDFVNII FNDSGHPFRF
     DTFPSEFNYV NIVITPESRA SFIASREAPP ADKQQFMPFY KVQLMSKPGF PTISPASETK
     MVSLKALPGF IRLLALNASV FSLVWANREG GDTVSSWRNR LREIKRLREK HGYTPATPTN
     HQITFGQSPF GPPQAGGSTP SPPTTSLGGG HHGGSLAAAT HSQAAADLSR PASSVRDSFG
     SSLRRSSVAT FFTSTSEQTS HRSSMLSTTT TTNDTEISPS TGLDSLVESV DFSRWA
//