ID A0A3M9Y2B3_9PEZI Unreviewed; 522 AA.
AC A0A3M9Y2B3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 14.
DE RecName: Full=cysteine desulfurase {ECO:0000256|ARBA:ARBA00012239};
DE EC=2.8.1.7 {ECO:0000256|ARBA:ARBA00012239};
GN Name=NFS1 {ECO:0000313|EMBL:RNJ54633.1};
GN ORFNames=D7B24_009587 {ECO:0000313|EMBL:RNJ54633.1};
OS Verticillium nonalfalfae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ54633.1, ECO:0000313|Proteomes:UP000267145};
RN [1] {ECO:0000313|EMBL:RNJ54633.1, ECO:0000313|Proteomes:UP000267145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ54633.1,
RC ECO:0000313|Proteomes:UP000267145};
RA Stajich J.E., Kasson M.T.;
RT "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU004504};
CC -!- SIMILARITY: Belongs to the class-V pyridoxal-phosphate-dependent
CC aminotransferase family. NifS/IscS subfamily.
CC {ECO:0000256|ARBA:ARBA00006490}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNJ54633.1}.
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DR EMBL; RBVV01000098; RNJ54633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M9Y2B3; -.
DR STRING; 1051616.A0A3M9Y2B3; -.
DR OrthoDB; 212394at2759; -.
DR Proteomes; UP000267145; Unassembled WGS sequence.
DR GO; GO:0031071; F:cysteine desulfurase activity; IEA:UniProtKB-EC.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0044571; P:[2Fe-2S] cluster assembly; IEA:InterPro.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR HAMAP; MF_00331; Cys_desulf_IscS; 1.
DR InterPro; IPR000192; Aminotrans_V_dom.
DR InterPro; IPR020578; Aminotrans_V_PyrdxlP_BS.
DR InterPro; IPR010240; Cys_deSase_IscS.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11601:SF34; CYSTEINE DESULFURASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11601; CYSTEINE DESULFURYLASE FAMILY MEMBER; 1.
DR Pfam; PF00266; Aminotran_5; 2.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00595; AA_TRANSFER_CLASS_5; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 102..361
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
FT DOMAIN 385..487
FT /note="Aminotransferase class V"
FT /evidence="ECO:0000259|Pfam:PF00266"
SQ SEQUENCE 522 AA; 57464 MW; 8C153C7853D7185B CRC64;
MASISTSALR QAGRLCRTTA ASPLRRLPST PRIIAGPIQQ FTQRRNVSET RQDHAQVNVD
TAIKLDKKDF IDQSPDGSNV VVSPMAEVLK QVTTMEEGQR PIYLDMQATT PVDPRVLDAM
LPFYTGIYGN PHSKTHAYGW ESESAVEEAR EHIAKLIGAD SKEIIFTSGA TESNNMSIKG
VARFFGRSGK KKHIITTQTE HKCVLDSCRH LQDEGFEITY LPVNNSGLID LAQLEAAIKP
ETALVSIMTV NNEIGVIQPM EEIGKLCRKN KVFFHTDAAQ AVGKMPLDVN AMNIDLMSIS
SHKIYGPKGI GACYVRRRPR VRLDPIITGG GQERGLRSGT LAPPLIVGFG EACRIAYEEM
EVRVTFLSLL PIFATIVVTQ HSYDSKRIKA LSDRLLGGLL SMEHTNQNGD PNHFYPGCVN
VSFAYVEGES LLMALKDIAL SSGSACTSAS LEPSYVLRAL GNSDESAHSS IRFGIGRFTT
EAEIDYVLKA VQERVDFLRE LSPLWELVQD GVDLSTIQWS QH
//
