ID A0A3M9Y970_9PEZI Unreviewed; 914 AA.
AC A0A3M9Y970;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=DNA replication licensing factor MCM2 {ECO:0000256|ARBA:ARBA00018925};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=MCM2 {ECO:0000313|EMBL:RNJ56068.1};
GN ORFNames=D7B24_007736 {ECO:0000313|EMBL:RNJ56068.1};
OS Verticillium nonalfalfae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ56068.1, ECO:0000313|Proteomes:UP000267145};
RN [1] {ECO:0000313|EMBL:RNJ56068.1, ECO:0000313|Proteomes:UP000267145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ56068.1,
RC ECO:0000313|Proteomes:UP000267145};
RA Stajich J.E., Kasson M.T.;
RT "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNJ56068.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; RBVV01000064; RNJ56068.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M9Y970; -.
DR STRING; 1051616.A0A3M9Y970; -.
DR OrthoDB; 5476523at2759; -.
DR Proteomes; UP000267145; Unassembled WGS sequence.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IEA:UniProt.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005656; C:nuclear pre-replicative complex; IEA:UniProt.
DR GO; GO:0043596; C:nuclear replication fork; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR GO; GO:0006279; P:premeiotic DNA replication; IEA:UniProt.
DR CDD; cd17753; MCM2; 1.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 3.30.1640.10; mini-chromosome maintenance (MCM) complex, chain A, domain 1; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008045; MCM2.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR027925; MCM_N.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF44; DNA REPLICATION LICENSING FACTOR MCM2; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF12619; MCM2_N; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF14551; MCM_N; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01658; MCMPROTEIN2.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:RNJ56068.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; Signal {ECO:0000256|SAM:SignalP};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT SIGNAL 1..36
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 37..914
FT /note="DNA replication licensing factor MCM2"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5017993814"
FT DOMAIN 522..728
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 39..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..775
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..914
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 64..80
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 914 AA; 101995 MW; 8E9BB4C65248D404 CRC64;
MEVTEDEPSL RLLFLLFLLF LLFLLFLLFL LTAAHSSPLR NHPSSANRGM PARSSRKRSR
TNGDDGSSVG LASSPMASSP PAFNIAHGGD DDDDIEEDVE IEDDLDDMDE AAEDDVDLFR
EGFEQDYRSK EDDRYEGIDI DDEGEYDQMD PATRRQLEAQ LARRDGEVAR RQRIPAAFLP
GEDDDGDIDL TAQPRRRRHA YDEDPDDAMD EDIMDEELSL EALQDVKAAS LTDWVSQSSV
QRTIRREFKS FLTEYIDESG SSVYGNRIRT LGEINAETLE VSYDHLSSSK AILAYFLANA
PAEMLKLFDE VAMDVVLLHY PDYERIHAEI HVRIFDLPVH YTLRQLRQSH LNCLVRVSGV
VTRRTGVFPQ LKYVKFDCTK CGVTLGPFQQ ESNVEVKISY CQSCQSRGPF TVNSEKTVYR
NYQKLTLQES PGTVPAGRLP RTREVILLWD LIDKAKPGEE IEVTGIYRNN YDAQLNNRNG
FPVFATILEA NNVVKSHDQL AGFRMTEEDE AAIRKLARDP GIIDKIVNSI APSIYGHTDI
KTAVALSLFG GVAKVGKGSH HVRGDINVLL LGDPGTAKSQ VLKYVEKTAH RAVFATGQGA
SAVGLTASVR RDPLTSEWTL EGGALVLADR GTCLIDEFDK MNDQDRTSIH EAMEQQTISI
SKAGIVTTLQ ARCGIIAAAN PIGGRYNSTI PFSANVELTE PILSRFDILC VVRDTVEPEE
DERLARFIVG SHSRSHPNPT LLSQDQDHDS MDVAAGDTQR SEAQKAKLEA EKRRKENEIP
QELLRKYILY ARDRLSPKLY HMDEDKVARL FADMRRESLA TGAYPITVRH LEAIIRISEA
FCRMRLSEYC SSHDIDRAIA VTVESFVGSQ KVSCKKALAR AFAKYTLARP GAGTQSQRST
GTSQASRRTG TAAA
//
