ID A0A3M9YBL0_9PEZI Unreviewed; 1933 AA.
AC A0A3M9YBL0;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PI4KA {ECO:0000313|EMBL:RNJ57156.1};
GN ORFNames=D7B24_006313 {ECO:0000313|EMBL:RNJ57156.1};
OS Verticillium nonalfalfae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ57156.1, ECO:0000313|Proteomes:UP000267145};
RN [1] {ECO:0000313|EMBL:RNJ57156.1, ECO:0000313|Proteomes:UP000267145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ57156.1,
RC ECO:0000313|Proteomes:UP000267145};
RA Stajich J.E., Kasson M.T.;
RT "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNJ57156.1}.
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DR EMBL; RBVV01000044; RNJ57156.1; -; Genomic_DNA.
DR STRING; 1051616.A0A3M9YBL0; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000267145; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:RNJ57156.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1363..1549
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1651..1917
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1933 AA; 214239 MW; 8DDA19400CB0D100 CRC64;
MSRDIRLKAL QKIAALSAAS STTSFDRSDL DRLCKACPPH GRSSNGYSSS QAVAIGRVPM
TIREFEVLLA LCKAAPSIKT SQSAQKLANQ LVPYILEAHV QAFVHSPFFK KIDPSPTEAL
AFHVTAALLS LGTNYDALEE VVSDSLWAFI NSCSHAAENI VPTSADPPEG PTLDNAIQTA
TIAISLLGFL EAAAAQADFW RAGGRLALIQ RVKELLSEPF LIAAETAFST IRNAHSPDRH
TKEWKRTLRH YSVIGRPLGA MLLQRSFMWL LVAATSLLTT DATTLRSTHV LDVHMSGTKQ
PEPSRAADVD IRSLDCYANM ALNQMDYLEA SADFVRLGSV GEQELAFAVK SAALISYLNC
SLINEDVADS DNVMSWLEEA LADPLQMADE TLASVVLRAM AITCRITPSY ANTVSRLLPR
FIVQTAPDSK TVTIASKSLA FVLRKLSQDA VITTLYTLGN VLSPGSDRAI ANGTMNDLSQ
DGPTSVYAGR HSMGSSISLQ ITGEEETAVV WGNVVQAVCG IAAACNDQKI TALAQSMLLQ
KIDKISPRVD AQIIIGAAAL ALKGGQLEFR SLLKMYSRIS HLGVSSDKGF LLDAVMKARV
HLSTHLRRGS PLYDIYWEHL LESVISIGDV HKSQTKDADL QLAAQEIAQL LRPLAVIMSA
NDLAFNNATD DESHTLIRDA WFNLVVHGFT VQSDLGILYQ DELRLMAIHS PPLVAEQRGE
QIESDIELNT VLRRGMSSER ETAKRKHLSD LVPLKDQEIK GLSYRKVIFL QSAYLVESLR
ADSGDCTKVL SYFLEPSMRR GDVSSTMEGI ATAVLEKYLR KTLGGQDSSF SAPFAASQLA
AVLCNCCHRI ERVQQAAFTY ADRIIRDVPS ALCHRTSLFA LLELLSLMWT SCLEAETDLY
APRSCFTSTL GGVSVEVSDD YDFRRKTLDN LHRRAKAWVS GVIGLAPLDV KGQLQTYLSE
FNDEGAYGHI SLGRSFALEM SAVIPSTDQR LQSLDLVGAC NINTASDFVA QYTTRQEYRY
GETLPDRGTE LVSFMHLNRR ASFVQSSVSS ASESNNAATA LAHVEARLRS KKSTPLSEVR
DILRRAAALL CRSSRDESDV VHYLVSIPFA MFTKESTKLG VSLWLGVMNE NPRLEPRLLS
EIAQQWELSI QRRLGLFSRT VTHPDPFFLR GESAPSDLEG IAKQRHHVHN LLSPHMRLMQ
FFASHFNATR LGSPDVQKIF LRILDITLDA ILTATPHPVA RELRYQIVLF GLKVVRACTT
IGAVALGRLK EKLLSAGLSW FRAAPRWSFG SNILQLKTEL RLLSDVVVSL KQVDAIGAQA
GGNLKSLKAK TQLLLLLIEN EHTRLSVWVH PLEPHKAHTL SHAAPKTALE NSLIPLVRTA
WAEDPSIAIE LVSRFQIPRL HQEVRWLLLN FPAKAVSEPE ALPILLGGTL PNDVSFQLKY
LLLWAPVNPI TAATYFSPTY RSNPYMTQYA MKALESHSSE VTFFYIPQIV QALRYDALGY
VERYILETAK FSQLFAHQII WNMKANAYKD DSGTIPDDIK PTLDTVQEKM VANFSDADRD
FYLREFAFFD EVTSISGKLK PFISRPKPEK AQKIEEELRK IKVDVGVYLP ISSDGVVIGI
DRKSGKPLQS HAKAPYMATF RVKKAKKSIA VDGEEMIEEV GKQAAQPQDN QTVEVWQSVI
FKVGDDCRQD VLALQMIAAF RGIFQSVGLD VYVFPNRVTA TAPGCGVIEV LPNSVSRDML
GREAVNGLYD YFISKYGNED SLRYQKARTN FVKSMAAYSV ISFLLQFKDR HNGNIMIDDA
GHILHIDFGF CFDIAPGGIK FERAPFKLTT EMMAVMGGAD HQAFKWFEEL TVKSFLASRQ
YCEKLSQIVL LMMDSGLPCF KPETVKHFRQ RFVLEKSERE AAEFMKDLIK KSAGSYSTGV
YDQFQLLTNG IPY
//
