ID A0A3M9YH86_9PEZI Unreviewed; 727 AA.
AC A0A3M9YH86;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 13-SEP-2023, entry version 12.
DE RecName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial {ECO:0008006|Google:ProtNLM};
GN ORFNames=D7B24_000650 {ECO:0000313|EMBL:RNJ59933.1};
OS Verticillium nonalfalfae.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Verticillium.
OX NCBI_TaxID=1051616 {ECO:0000313|EMBL:RNJ59933.1, ECO:0000313|Proteomes:UP000267145};
RN [1] {ECO:0000313|EMBL:RNJ59933.1, ECO:0000313|Proteomes:UP000267145}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VnAa140 {ECO:0000313|EMBL:RNJ59933.1,
RC ECO:0000313|Proteomes:UP000267145};
RA Stajich J.E., Kasson M.T.;
RT "Genome sequence of Verticillium nonalfalfae VnAa140.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNJ59933.1}.
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DR EMBL; RBVV01000011; RNJ59933.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3M9YH86; -.
DR STRING; 1051616.A0A3M9YH86; -.
DR OrthoDB; 1459320at2759; -.
DR Proteomes; UP000267145; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}.
FT DOMAIN 35..485
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 151..351
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 643..718
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 727 AA; 78953 MW; 30F5437FF8A2AE68 CRC64;
MRSMKAKHRL ARPLPRLLST AATGVSASAA PQITPITSLL IANRGEIALR IHKTADRLGI
RTTTLYTDPD ASSQHAACSP HSLSLGNPKA YLDGDRIISL AKQHGIQALH PGYGFLSENP
AFASRCEKEG IVFVGPPAKA MHDMGDKARS KEIMTAAGVP CVPGYHGADQ EEAQLLQHAR
EVRFPVLLKS VKGGGGKGMR IVLTEDEFPA QLRSARLEAK ASFGDGGEVM LVEKYIVRPR
HVEVQVFADK HGNCVALGER DCSVQRRHQK ILEESPAPCL DEATRLDLWD KARKAASAVD
YVGAGTVEFI LDRDTGEFYF MEMNTRLQVE HPVSEMVTGT DLVEWQLNIA AGEKLPMTQE
EISEAISQRG AAIEARIYAE SPEKGFMPDS GKLVHLTTPA TDPDVRIDAG FVQGDTVSEA
YDGMIAKLIV RGRDRETAIR RLELALRDYE VVGLSTNIEF LKRMCRSPAF IEGDVETGFI
EKWKDELFAP RVITDEVFVQ AALGSLTAQL ASEAPHGGSL GFGAPNTATE RSFALKVLDA
YSKQDGEVVQ VTVSQTSPGM FSATVTRKGA EPEVIEKIAC TSSTPKSLAT KLTTFFPGER
IHSTVVRTTP NATETQDSKV VVFQHGVRTE LALLPPKWFE KALGLKEIAA SVVAPMPCKV
LRNEVAEDEV VKKGAPLVVI ESMKMETVIR SPQDGVVKKL AHKEGDICKA GTVLVLFEEE
AAANEAS
//
