ID A0A3N0BXH9_9MICC Unreviewed; 642 AA.
AC A0A3N0BXH9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:RNL54418.1};
DE EC=3.7.1.22 {ECO:0000313|EMBL:RNL54418.1};
GN Name=iolD {ECO:0000313|EMBL:RNL54418.1};
GN ORFNames=D7003_11390 {ECO:0000313|EMBL:RNL54418.1};
OS Arthrobacter oryzae.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=409290 {ECO:0000313|EMBL:RNL54418.1, ECO:0000313|Proteomes:UP000273807};
RN [1] {ECO:0000313|EMBL:RNL54418.1, ECO:0000313|Proteomes:UP000273807}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TNB02 {ECO:0000313|EMBL:RNL54418.1,
RC ECO:0000313|Proteomes:UP000273807};
RA Cho Y.-J., Cho A., Kim O.-S.;
RT "Genome sequencing of Arthrobacter oryzae TNB02.";
RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNL54418.1}.
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DR EMBL; RBED01000101; RNL54418.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N0BXH9; -.
DR OrthoDB; 3194735at2; -.
DR Proteomes; UP000273807; Unassembled WGS sequence.
DR GO; GO:0102481; F:3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase activity; IEA:UniProtKB-EC.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR030817; Myo_inos_IolD.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR PANTHER; PTHR18968:SF9; 3D-(3,5_4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:RNL54418.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000273807};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 1..134
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 222..356
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 420..595
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 642 AA; 69682 MW; 88F1AE0456524597 CRC64;
MTVAQAVVEY LSRQYTVDTI GGQEYRERLI PGTFGIFGHG NVAGVGQALK QYQAADPTIM
PYYQGRNEQA QVHQAVGYAR HTRRRQTFAI STSIGPGSSN LLTGAALATT NRLPVLLLPS
DTFATRVADP VLQQLERPDA YDITVNDAFR PLSKFFDRVS RPEQLFSAFH HGLRVLTDPA
ETGAVTISLP QDVQAEAFDV PEEFLAEREW RIRRPDADDE DIRRAAAAIR AARNPLIIAG
GGVLYAYAND ELARLVELTG IPVGNTQAGV GVLPWDHPFS VGAIGSTGTT AANALAADAD
LIIGIGTRYE DFTTASRTAF QNPEVQFINI NVAPIDAYKH GTALPIVADA RRALIKLNQA
LGGYRVGADL EQRIAAEKKR WNATVDEAFG TRFTPLPAQN EIIGATSRAM DAQDVVICAA
GSLPGDLHKM WRVRDPFGYH VEYAYSCMGY EIPGGLGVKR AALAEAAAGG AQRDVVVMVG
DGSYLMMHTE LVTAVAERIN LIVVLIQNHG YASIGSLSES LGSQRFGTQY RELDEETHSF
DAGERLPVDL ALNAESLGVK VIRIEPGEKV IAELEQAVRD AKAAPERGGP IVIHVESDPL
LDAPASESWW DVPVSQVSDL DSTRQAYTTY TDHKNRQRKL LG
//
