ID   A0A3N0CIS4_9ACTN        Unreviewed;       327 AA.
AC   A0A3N0CIS4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha {ECO:0000313|EMBL:RNL62843.1};
GN   ORFNames=EFK50_13985 {ECO:0000313|EMBL:RNL62843.1};
OS   Nocardioides marmoriginsengisoli.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=661483 {ECO:0000313|EMBL:RNL62843.1, ECO:0000313|Proteomes:UP000267128};
RN   [1] {ECO:0000313|EMBL:RNL62843.1, ECO:0000313|Proteomes:UP000267128}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Gsoil 097 {ECO:0000313|EMBL:RNL62843.1,
RC   ECO:0000313|Proteomes:UP000267128};
RA   Li F.;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNL62843.1}.
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DR   EMBL; RJSE01000007; RNL62843.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N0CIS4; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000267128; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267128}.
FT   DOMAIN          13..308
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   327 AA;  35412 MW;  0016724542B729CB CRC64;
     MEGEGLNVEL FQRLVFTRRF LEKVDTLYRQ GRVRGPAHLG LGQEAIAVGV GSLLRPGDRS
     IGTYRGHAHA LARGASPESM LRELLGREGG ICAGKGGSMH ITSVEHGYYG SYAIVGAHLT
     IANGLAWADQ IQRNDAVTVC FFGDGTVNIG AFHEAVTLAA VWKLPVVFVC ENNQYMEYTP
     ISAMIPTARP AADKAAAYGM TSIVVDGNDL TEVRRVIGAA IEDARCGRGP ALVEADTYRL
     KGHSAADAGK YRPAEEVERW RARDPLLVYR EQLIAAELLD DSAADQMWTD ARDELNALTE
     VVLKAPPPDA SGAWTDLWSD GSSSWRN
//