ID A0A3N0DXF3_9ACTN Unreviewed; 679 AA.
AC A0A3N0DXF3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Cadmium-translocating P-type ATPase {ECO:0000313|EMBL:RNL80133.1};
DE EC=3.6.3.3 {ECO:0000313|EMBL:RNL80133.1};
GN Name=cadA {ECO:0000313|EMBL:RNL80133.1};
GN ORFNames=EFL95_14585 {ECO:0000313|EMBL:RNL80133.1};
OS Nocardioides marmorisolisilvae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Nocardioides.
OX NCBI_TaxID=1542737 {ECO:0000313|EMBL:RNL80133.1, ECO:0000313|Proteomes:UP000277094};
RN [1] {ECO:0000313|EMBL:RNL80133.1, ECO:0000313|Proteomes:UP000277094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIS18-7 {ECO:0000313|EMBL:RNL80133.1,
RC ECO:0000313|Proteomes:UP000277094};
RA Li F.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}.
CC -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC ECO:0000256|RuleBase:RU362081}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNL80133.1}.
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DR EMBL; RJSG01000002; RNL80133.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N0DXF3; -.
DR OrthoDB; 7059309at2; -.
DR Proteomes; UP000277094; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00371; HMA; 1.
DR CDD; cd02094; P-type_ATPase_Cu-like; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR017969; Heavy-metal-associated_CS.
DR InterPro; IPR006121; HMA_dom.
DR InterPro; IPR036163; HMA_dom_sf.
DR InterPro; IPR027256; P-typ_ATPase_IB.
DR InterPro; IPR001757; P_typ_ATPase.
DR NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR NCBIfam; TIGR01512; ATPase-IB2_Cd; 1.
DR NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR NCBIfam; TIGR01494; ATPase_P-type; 1.
DR PANTHER; PTHR43520; ATP7, ISOFORM B; 1.
DR PANTHER; PTHR43520:SF8; COPPER-TRANSPORTING ATPASE 2; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00403; HMA; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
DR PROSITE; PS01229; COF_2; 1.
DR PROSITE; PS01047; HMA_1; 1.
DR PROSITE; PS50846; HMA_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU362081};
KW Cell membrane {ECO:0000256|RuleBase:RU362081};
KW Hydrolase {ECO:0000313|EMBL:RNL80133.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU362081};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW Reference proteome {ECO:0000313|Proteomes:UP000277094};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362081};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362081}.
FT TRANSMEM 84..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 108..130
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 142..160
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 166..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 317..340
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 629..646
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT TRANSMEM 652..670
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362081"
FT DOMAIN 3..67
FT /note="HMA"
FT /evidence="ECO:0000259|PROSITE:PS50846"
SQ SEQUENCE 679 AA; 69621 MW; CD5C214F6CF942AA CRC64;
MTSEVDLELT GMTCASCANR IERKLNKLDG VAATVNFATE KAHVAFPDTL TPADLVATVE
AAGYGASLPA GEPRATGDDG RTRLLVSALL TVPVVVLGMA WHVDGWRWIS LVLATPVVFW
GGAGFHRAAW TNLRHGATTM DTLVSLGTLA AYGWSVVSLV GGGELYLEAA AVVTTFLLAG
RFLEARAKSR SGDALRALLE LGAKDVAVLR DGVETRIEVA GLRVGDLFVV RPGEKLATDG
VVEEGASAVD ASLLTGEPVP VEVGPGDDVV GGCINAGGRL VVRATRVGAD TQLAQMARLV
EQAQFGKAPV QRLADRISAV FVPVVIALAI ATLLGWLLAG QSATDAFTAA VAVLIIACPC
ALGLATPTAL MVGTGRGAQL GILIKGPEVL EQTRRANVVV LDKTGTVTTG RMTVQQFTSD
ETLRLAGAAE SGSEHPIAKA IVAAAGEVPP ATEFASTPGV GVTATVGGHR IEVRRAATAA
AGTTVDVVCD GETVGSIVVA DEPRPTSAEA VARLKGLGLR PVLLTGDNRS VATSIATAVG
IEDVVAEVLP ADKVDVVRRL QSEGDVVAMV GDGVNDAAAL AQADLGIAMG TGSDVAIEAS
DLTLVRDDLL VAVDAIRLSR RTLGIIRGNL FWAFAYNVAG LPLAAAGLLN PMIAGGAMAL
SSVFVVGNSL RLRSFRTTS
//
