ID A0A3N0DXG9_9ACTN Unreviewed; 350 AA.
AC A0A3N0DXG9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
GN ORFNames=EFL95_14965 {ECO:0000313|EMBL:RNL80196.1};
OS Marmoricola solisilvae.
OC Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC Nocardioidaceae; Marmoricola.
OX NCBI_TaxID=1542737 {ECO:0000313|EMBL:RNL80196.1, ECO:0000313|Proteomes:UP000277094};
RN [1] {ECO:0000313|EMBL:RNL80196.1, ECO:0000313|Proteomes:UP000277094}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KIS18-7 {ECO:0000313|EMBL:RNL80196.1,
RC ECO:0000313|Proteomes:UP000277094};
RA Li F.;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:RNL80196.1}.
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DR EMBL; RJSG01000002; RNL80196.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N0DXG9; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000277094; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:RNL80196.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000277094};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 45..92
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 104..313
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 350 AA; 38949 MW; 3CFC8C77AD08C682 CRC64;
MGRRRGADRL GCCRRGRVPG QGSGVRLRTV SCQQPGWRRI RHGRGFRYLD EHGEPLAADD
VERVRDLVIP PAWTDVWICP YPRGHLQAVG TDDAGRRQYL YHPQWREQRD LEKFERVTAL
ASTFPGMRRK LRHQLLAPAG DDDVERRRVL AAGVRLIDLG CFRPGSEESA DEFGSHGLTT
LERHHVRREH SVLMFRFSGK AGIEHEVLVE DPNLVSALES ALKRPGGARL LASKVGARWK
PITAEELNEH IRAVTGLDMT AKDFRTWHAT VTAAVVLAES PIPTSASGRK KRIREAVVAA
SELLGNTPTV ARSAYVDPRI IDLFESGTVL DPIPGGSDAL DRAVVRLLND
//