ID   A0A3N0E0H0_9ACTN        Unreviewed;       497 AA.
AC   A0A3N0E0H0;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=Potassium/proton antiporter {ECO:0000313|EMBL:RNL81348.1};
GN   ORFNames=EFL95_03065 {ECO:0000313|EMBL:RNL81348.1};
OS   Nocardioides marmorisolisilvae.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=1542737 {ECO:0000313|EMBL:RNL81348.1, ECO:0000313|Proteomes:UP000277094};
RN   [1] {ECO:0000313|EMBL:RNL81348.1, ECO:0000313|Proteomes:UP000277094}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIS18-7 {ECO:0000313|EMBL:RNL81348.1,
RC   ECO:0000313|Proteomes:UP000277094};
RA   Li F.;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:RNL81348.1}.
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DR   EMBL; RJSG01000001; RNL81348.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N0E0H0; -.
DR   OrthoDB; 9810759at2; -.
DR   Proteomes; UP000277094; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   Gene3D; 1.20.1530.20; -; 1.
DR   Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR038770; Na+/solute_symporter_sf.
DR   InterPro; IPR006037; RCK_C.
DR   InterPro; IPR036721; RCK_C_sf.
DR   PANTHER; PTHR32507:SF7; K(+)_H(+) ANTIPORTER NHAP2; 1.
DR   PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF02080; TrkA_C; 1.
DR   SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR   PROSITE; PS51202; RCK_C; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000277094};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..30
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        37..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        62..80
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        92..116
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        192..210
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..312
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        333..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        362..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          401..482
FT                   /note="RCK C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51202"
SQ   SEQUENCE   497 AA;  51862 MW;  777878EEF4BF260C CRC64;
     MTLDVHTLNQ GLLAGTGVLL VAIVAVRASV RAGLPSLLLY LLIGVGLGDA GLGVSFSDAE
     LANALGFAAL IIILAEGGLT THWGEMRPVI KLGLSLATLG VAVSVGIVAL VAHFALGMSW
     QLAVLLGALT SPTDAAAVFS VLRRVPLPRR INATLEAESG LNDAPTVVLV TLVSASGHHG
     ALNFLGEVVS ELLIGTAGGL LVGFAGAWLM RRAALPSSGL YPLAVLSFAV FAYAGTATLH
     GSGFAAVYVA ALVLGNSELP HRAATRSFAE GMAWLSQIGL FVMLGLLVSP SGFTWKVLGI
     AVVAVLVLTV IARPVSVLVS ALVQPIPLPE LGFISWAGLR GAVPIVLATI PLSAGVHKAT
     ELFNVVFVLV VIDTLITAPT LPWVARVLKV ARRSEPRDLD VEAAPLERIA ADLLMITISP
     KSLMHGVEVA ELRLPKGSSV SLIVRDGSTL VPQDRTSLRH GDELLVVTTR KGREKTEERL
     RSVSLRGRLA QWNDDVS
//