ID   A0A3N0UZF2_9PROT        Unreviewed;       449 AA.
AC   A0A3N0UZF2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 19.
DE   SubName: Full=Methyltransferase domain-containing protein {ECO:0000313|EMBL:ROH85929.1};
GN   ORFNames=ED236_08895 {ECO:0000313|EMBL:ROH85929.1};
OS   Pseudomethylobacillus aquaticus.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Methylophilaceae; Pseudomethylobacillus.
OX   NCBI_TaxID=2676064 {ECO:0000313|EMBL:ROH85929.1, ECO:0000313|Proteomes:UP000275137};
RN   [1] {ECO:0000313|EMBL:ROH85929.1, ECO:0000313|Proteomes:UP000275137}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H-5 {ECO:0000313|EMBL:ROH85929.1,
RC   ECO:0000313|Proteomes:UP000275137};
RA   Chen W.-M.;
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RsmB/NOP family. {ECO:0000256|ARBA:ARBA00007494,
CC       ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROH85929.1}.
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DR   EMBL; RJVP01000004; ROH85929.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N0UZF2; -.
DR   Proteomes; UP000275137; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR018314; Fmu/NOL1/Nop2p_CS.
DR   InterPro; IPR031341; Methyltr_RsmF_N.
DR   InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR   InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR   InterPro; IPR023267; RCMT.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR   PANTHER; PTHR22807:SF77; SUN PROTEIN; 1.
DR   Pfam; PF01189; Methyltr_RsmB-F; 1.
DR   Pfam; PF17125; Methyltr_RsmF_N; 1.
DR   PRINTS; PR02008; RCMTFAMILY.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS01153; NOL1_NOP2_SUN; 1.
DR   PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}; Reference proteome {ECO:0000313|Proteomes:UP000275137};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW   ProRule:PRU01023};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01023};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW   ProRule:PRU01023}.
FT   DOMAIN          138..415
FT                   /note="SAM-dependent MTase RsmB/NOP-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51686"
FT   ACT_SITE        352
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         252
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT   BINDING         299
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ   SEQUENCE   449 AA;  49377 MW;  DBBC7D7D06C1545F CRC64;
     MSSNLLRLAA VALVDVLGNR GPADVKLSWF FKQNRELGTK DRAFVAESVY GVLRRKALLS
     HLAEGEDPRK LLLAWLLRVQ GHSLRELDGA LNKQQLEWAH AIKAVSTDAL PPAVQADLPE
     WLWQWLSAQY GEAEALIIAR SMHQPAPLDL RVNLIKATRE EVQAKLASEK TEIAPTPYSP
     QGLRMTQKMN ISRHPWFMEG KFEVQDEGSQ LLAQLVAPRR GQMVADFCAG AGGKSLALGA
     IMRNSGRIYA FDVSEKRLLN LGQRLKRSGL SNLHSQLITS ENDPKLKRLD GKFDRVLVDA
     PCSGLGTLRR NPDLKWRMTE QDLTELVAKQ AGILARAARL VKPGGRLVYA TCSLLQQENE
     QQAQAFLSAH PQFVLVPAGP LLAQQQVVLD TGDFLQLLPH KHQTDGFFAA VFEKAVPVGA
     PAAAADEVEA DKLVAEAEVT DKAEADAQP
//