ID A0A3N1A7R1_9ACTN Unreviewed; 731 AA.
AC A0A3N1A7R1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=EDC02_7644 {ECO:0000313|EMBL:ROO52704.1};
OS Micromonospora sp. Llam0.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2485143 {ECO:0000313|EMBL:ROO52704.1, ECO:0000313|Proteomes:UP000275308};
RN [1] {ECO:0000313|EMBL:ROO52704.1, ECO:0000313|Proteomes:UP000275308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Llam0 {ECO:0000313|EMBL:ROO52704.1,
RC ECO:0000313|Proteomes:UP000275308};
RA D'Agostino P.;
RT "Genome mining of underrepresented organisms for secondary metabolites.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROO52704.1}.
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DR EMBL; RJJY01000002; ROO52704.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N1A7R1; -.
DR OrthoDB; 3196525at2; -.
DR Proteomes; UP000275308; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.30.2310.20; RelE-like; 1.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR035093; RelE/ParE_toxin_dom_sf.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF143011; RelE-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000275308}.
FT DOMAIN 250..530
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 271..278
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 731 AA; 80415 MW; 836EF85274F70482 CRC64;
MAKVNVLFAD TFDKAYQNLD ATIQRRVVDF MLKLRKDPDA AGLNLKQPHG AHDKRVWTAR
VNDNFRAVLW RPDHTTFYLA SIKPHDDAYT YAAQTVWNVN KVTGGVEFYD HGAIQEVLLR
TGDSLPAARD RPGFFDQVSD ADFARLGIAS TLTPTLREIR TEDALLGIAE QVPKLASQVI
LALADGRTTD EVWADIVTQS EADDTVDPDD VAAATERPAT RESFAVVTDD SEELERMLLK
PMSEWRIFLH PQQRRLAYRA KPYNGPARVS GGPGTGKTVV ALHRVKALAA DIPSGAGRKI
LLTTYTNALS DLLHRLLDDL GGPDLTAKVD VLNIDKLVRD VLRNDAESQW VNVEILGDAA
IAARWNDVIT GLSTNGSFDR PFLISEWEQV VLAQNIRTRE EYFSARRSGR GRRLTRSDRA
TVWSLIQEFE RRLDRDQALG FKQAAVRAGD ATANWTDADR PYQHVIVDEA QDLHAAHWTL
LRAMVPAGPD DLFIVGDAFQ RIYDNRITLG KLGIDIRGRS HRLTLNYRTT RQILSAAINV
IDPDGYDDLD GGSDSLRGYR SILRGGTPEV AGYTSPTAEM AALADRIRRW HSGGIPLDEI
AVIARTNATA TTAVTALQAA GLDATLARSG QTTAPEKGIQ AMTMHRAKGL EFRAVAIIGA
STRNLPLPAA VTPAETDYLD HQRDIQRERS LLFVSATRAR EALSITWSGQ PSHFLTGLVR
TVTGGSAGLG G
//
