ID A0A3N1AT18_9ACTN Unreviewed; 340 AA.
AC A0A3N1AT18;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Methyltransferase family protein {ECO:0000313|EMBL:ROO59942.1};
GN ORFNames=EDC02_1789 {ECO:0000313|EMBL:ROO59942.1};
OS Micromonospora sp. Llam0.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2485143 {ECO:0000313|EMBL:ROO59942.1, ECO:0000313|Proteomes:UP000275308};
RN [1] {ECO:0000313|EMBL:ROO59942.1, ECO:0000313|Proteomes:UP000275308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Llam0 {ECO:0000313|EMBL:ROO59942.1,
RC ECO:0000313|Proteomes:UP000275308};
RA D'Agostino P.;
RT "Genome mining of underrepresented organisms for secondary metabolites.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROO59942.1}.
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DR EMBL; RJJY01000001; ROO59942.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N1AT18; -.
DR OrthoDB; 582216at2; -.
DR Proteomes; UP000275308; Unassembled WGS sequence.
DR GO; GO:0008171; F:O-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000313|EMBL:ROO59942.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000275308};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000313|EMBL:ROO59942.1}.
FT DOMAIN 7..91
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 135..318
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 246
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 340 AA; 37219 MW; BAF8635F6DB27774 CRC64;
MLTPTPLMRL VTGFWSFKTL AAAVELNLFT RLAGGRTITV GQLCDEYGLA ERPADTLLAA
CASLGLLTKQ PGSNSYRNAP IAEEFLVAGR PYYFGGQVRY CDERTYLPWH RIGEALRTDR
PLTWDPDTQE SIFADVDPRI LNLFLEAMYA ASIFTARALG DAYDFSAHHR LLDLGGGSGA
YPIELCRRYP HLRASVYDLP HVVPVAAEKA TAAGLADRID TVAGDFFTDE KLPQGHDVIL
LSMILHDWDE PTNRALLARC HDALPSGGTI VVCELLLNPE RTGPPEAALM GMNMLVETEG
GRNYSETEYA DWLADAGFGS IRTVVFDAPG ANGALIARKR
//
