ID   A0A3N1AU83_9ACTN        Unreviewed;      1049 AA.
AC   A0A3N1AU83;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=Replicative superfamily II helicase {ECO:0000313|EMBL:ROO60362.1};
GN   ORFNames=EDC02_2225 {ECO:0000313|EMBL:ROO60362.1};
OS   Micromonospora sp. Llam0.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=2485143 {ECO:0000313|EMBL:ROO60362.1, ECO:0000313|Proteomes:UP000275308};
RN   [1] {ECO:0000313|EMBL:ROO60362.1, ECO:0000313|Proteomes:UP000275308}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Llam0 {ECO:0000313|EMBL:ROO60362.1,
RC   ECO:0000313|Proteomes:UP000275308};
RA   D'Agostino P.;
RT   "Genome mining of underrepresented organisms for secondary metabolites.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROO60362.1}.
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DR   EMBL; RJJY01000001; ROO60362.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1AU83; -.
DR   OrthoDB; 491589at2; -.
DR   Proteomes; UP000275308; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd17921; DEXHc_Ski2; 1.
DR   Gene3D; 1.10.3380.20; -; 1.
DR   Gene3D; 3.40.50.1460; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011600; Pept_C14_caspase.
DR   PANTHER; PTHR47961:SF10; ATP-DEPENDENT DNA HELICASE HEL308; 1.
DR   PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF00656; Peptidase_C14; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ROO60362.1};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275308}.
FT   DOMAIN          316..488
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          532..727
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   1049 AA;  111017 MW;  9F0D897542C5CB64 CRC64;
     MVGSPATGSA RQFHGLFVGI NRYRSKSVRR LASAARDAKA LYAVFSDNLG DANTTLLVDR
     DATRDALVAA LVQLQTCSKP EDVVVISFSG HGSTTHELVT HDADPDNLPS TSLPLGQFTD
     LVSAIPARQL VVVLDCCFAG GAGAKVLNAP LVPRGGVTGL PESTDARLER MAGTGRLILA
     AATGEQEAWE DPHLGHGLLT YHLLRALLGA GAGDGGQVRL YDLLAFVTRE VKAKASGTVA
     AEQDPSLRGQ MDGELQWPVF TDTGPLYSAQ FPSSVLDPVT RDLASLRGHG IPQVVLDAWA
     ARIDELNDLQ VDTINQGRLL AGANVLVTAP TSSGKTMIGE LAAVRAARLG GRSVFLLPTR
     ALVNEQYARF TRTYVPAGLQ TIRATGETAD DVPALLQGQF DLAVLTYEKF AGLALGNPHL
     LKLISVVVID EVQTIVDPGR GAYLEFLLTV LKARRPEGVA PQVVALSAVL GDLGGLDSWL
     DANVIARTER PVPLLEGVLG PDGIYRHVNA DGEEVSERLI TPTGWTQRNQ DLIIPLVRKL
     VGQDQQVIIF RSTRGLTRGC ARYLARSLGL PEAKAALESL AGADPSAVLA DLRQCLAGGV
     AFHISDLARD EKIAIEDQFR ATGSGIRVLV CTTTLAQGVN LPAETVIIVE LDHPTGPAQT
     APYSVAEYKN IAGRAGRLGL TAGGRAVLIA AGGIDGDHRW RDYVLGTPED LRSQLLDPQQ
     DAATLLLRVV AVAARREGVT GLSEADVIAY LSNSFAAHQQ RMAGAPDPFP AATVSAVLSD
     LVGAGLLSSD PSGIELTELG TYVSQSGLRV SSAVRVARAL RAVYPGALNR VTIIAAAQLT
     DEVATARPPV NGRGWQKEQT TYIGELQRHG LAGPVLAALP GRERKTAAER AKRAVACIWW
     MAGVPIGRIE QQLMVHMPSK DAAGATRASA DRTQSVVGTV IDIARCLHPD AHLDDLARVL
     PVQLEFGIPP ELVSLAQRAG AALDRTDYLR LASRSLTEPE AVLDADDDIL LPCLNGNTSK
     LKALRQAARA ARDGDDSTDF ADLLPASID
//