ID A0A3N1AVQ4_9ACTN Unreviewed; 553 AA.
AC A0A3N1AVQ4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=DNA polymerase-1 {ECO:0000313|EMBL:ROO60896.1};
GN ORFNames=EDC02_2814 {ECO:0000313|EMBL:ROO60896.1};
OS Micromonospora sp. Llam0.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2485143 {ECO:0000313|EMBL:ROO60896.1, ECO:0000313|Proteomes:UP000275308};
RN [1] {ECO:0000313|EMBL:ROO60896.1, ECO:0000313|Proteomes:UP000275308}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Llam0 {ECO:0000313|EMBL:ROO60896.1,
RC ECO:0000313|Proteomes:UP000275308};
RA D'Agostino P.;
RT "Genome mining of underrepresented organisms for secondary metabolites.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROO60896.1}.
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DR EMBL; RJJY01000001; ROO60896.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N1AVQ4; -.
DR Proteomes; UP000275308; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000275308}.
FT DOMAIN 334..512
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..61
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..61
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 553 AA; 57738 MW; 817123E54660EC1D CRC64;
MAVAAGPGGG GVRRLLHADG RPAGPVEAVP DLAAAVDRPP PSQAPAAGLP PSQPPAARPV
PEPRWLWATT AAIYPALLRA GVRVERCHDV ELTEALLLGY DGRWGEPRSL AAAYARLTGA
PVPPDPPAPG AAPPGHGQTA LFDDVPAPAT VADPIDALTR VYADQQRRIA GTARPERFRL
LVAAESAGAL VAAEMGAAGL PLRADLHDAL LTELLGAPSP VGGPPRRLAE LAGRIAAAFG
VRQLHADSPA EVLRAFARVG ISLPNTRAWV LRGVDHPAVP LLIEYKELHR IWTAHGWAWR
QAWVRDGRFR PEYVPGGVVS GRWATRGGGA LQIPKAVRRA VVADPGWCFV VADAAQLEPR
VLAAMSGDRR LAAAGGAGDL YAALARDSFG GDRARAKVAL LGAMYGQTGG AAVPALAVLR
RSYPVAFEYL ESAARTGETG GLVRSWLGRT CPPSDVGTPA RGRFTRNFVA QATAAEWALI
LLATVRQAIA GTAAELVFFQ HDEVVVHCPA TQAAAVAVAV RECAGRATTV LFGDTPVRVP
LEVSTVTCYA DAT
//
