ID   A0A3N1CWE4_9ACTN        Unreviewed;       307 AA.
AC   A0A3N1CWE4;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=3,4-dihydroxy-9,10-secoandrosta-1,3, 5(10)-triene-9,17-dione 4,5-dioxygenase {ECO:0000313|EMBL:ROO85610.1};
GN   ORFNames=EDD29_3156 {ECO:0000313|EMBL:ROO85610.1};
OS   Actinocorallia herbida.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Thermomonosporaceae; Actinocorallia.
OX   NCBI_TaxID=58109 {ECO:0000313|EMBL:ROO85610.1, ECO:0000313|Proteomes:UP000272400};
RN   [1] {ECO:0000313|EMBL:ROO85610.1, ECO:0000313|Proteomes:UP000272400}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 44254 {ECO:0000313|EMBL:ROO85610.1,
RC   ECO:0000313|Proteomes:UP000272400};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROO85610.1}.
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DR   EMBL; RJKE01000001; ROO85610.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1CWE4; -.
DR   OrthoDB; 6909416at2; -.
DR   Proteomes; UP000272400; Unassembled WGS sequence.
DR   GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004462; F:lactoylglutathione lyase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   CDD; cd07237; BphC1-RGP6_C_like; 1.
DR   CDD; cd07252; BphC1-RGP6_N_like; 1.
DR   Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR   InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR   InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR   InterPro; IPR018146; Glyoxalase_1_CS.
DR   InterPro; IPR037523; VOC.
DR   PANTHER; PTHR21366; GLYOXALASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR21366:SF34; IRON-DEPENDENT EXTRADIOL DIOXYGENASE; 1.
DR   Pfam; PF00903; Glyoxalase; 1.
DR   SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR   PROSITE; PS00934; GLYOXALASE_I_1; 1.
DR   PROSITE; PS51819; VOC; 2.
PE   4: Predicted;
KW   Dioxygenase {ECO:0000313|EMBL:ROO85610.1};
KW   Oxidoreductase {ECO:0000313|EMBL:ROO85610.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000272400}.
FT   DOMAIN          4..119
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
FT   DOMAIN          143..261
FT                   /note="VOC"
FT                   /evidence="ECO:0000259|PROSITE:PS51819"
SQ   SEQUENCE   307 AA;  34045 MW;  D6F7886B96F0EC23 CRC64;
     MISQLAYLGI ASPKAEEWRQ YATRLLGAVL AEDGSDGAVR VKVDDAGYRI AVHPAAEDEL
     RYVGWACNNE TALRSYVAEL RAKGVELHEG DAEVLKERQV AELYWFTDPF GNRHELVWGQ
     HSTPNSFFPG RPMRGRFVTG DLGLGHVVLI VPDLQAADDF YAATLGFRLS DRVKSDIFNL
     RFYHCNGRHH SLAVAEIPGM TGINHLMLEV ESFDDLGTAI DLFTEDADRE ILLSLGRHTN
     DLMTSIYVQT PSSLQIEYGH GGIAVDDLTW VAGSHDLPSI WGHHRSQAYI DGPPGIFREL
     EGTEAAQ
//