ID A0A3N1ISD3_9ENTR Unreviewed; 310 AA.
AC A0A3N1ISD3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=p-hydroxybenzoic acid efflux pump subunit AaeA {ECO:0000256|HAMAP-Rule:MF_01544};
DE Short=pHBA efflux pump protein A {ECO:0000256|HAMAP-Rule:MF_01544};
GN Name=aaeA {ECO:0000256|HAMAP-Rule:MF_01544};
GN ORFNames=EDF81_3169 {ECO:0000313|EMBL:ROP58014.1};
OS Enterobacter sp. BIGb0383.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter.
OX NCBI_TaxID=2485118 {ECO:0000313|EMBL:ROP58014.1, ECO:0000313|Proteomes:UP000280899};
RN [1] {ECO:0000313|EMBL:ROP58014.1, ECO:0000313|Proteomes:UP000280899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BIGb0383 {ECO:0000313|EMBL:ROP58014.1,
RC ECO:0000313|Proteomes:UP000280899};
RA Samuel B.;
RT "Genomic analyses of the natural microbiome of Caenorhabditis elegans.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Forms an efflux pump with AaeB. {ECO:0000256|HAMAP-
CC Rule:MF_01544}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01544};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01544}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477, ECO:0000256|HAMAP-
CC Rule:MF_01544}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROP58014.1}.
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DR EMBL; RJKQ01000003; ROP58014.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N1ISD3; -.
DR Proteomes; UP000280899; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR HAMAP; MF_01544; AaeA; 1.
DR InterPro; IPR039562; MFP_biotin_lipoyl_2.
DR InterPro; IPR022871; PHBA_efflux_pump_AaeA.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30367:SF12; P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA; 1.
DR PANTHER; PTHR30367; P-HYDROXYBENZOIC ACID EFFLUX PUMP SUBUNIT AAEA-RELATED; 1.
DR Pfam; PF13533; Biotin_lipoyl_2; 1.
DR Pfam; PF13437; HlyD_3; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Membrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Reference proteome {ECO:0000313|Proteomes:UP000280899};
KW Transmembrane {ECO:0000256|HAMAP-Rule:MF_01544};
KW Transmembrane helix {ECO:0000256|HAMAP-Rule:MF_01544};
KW Transport {ECO:0000256|HAMAP-Rule:MF_01544}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01544"
FT DOMAIN 47..94
FT /note="Membrane fusion protein biotin-lipoyl like"
FT /evidence="ECO:0000259|Pfam:PF13533"
SQ SEQUENCE 310 AA; 34276 MW; C247F0E7EBAE99A2 CRC64;
MKTLTTKISR TAITLVLVVL AFIAIFRAWA YYTESPWTRD ARFSADVVAI APDVAGLITQ
VSVKDNQLVK KNQVLFTIDQ PRYQKALEEA QADVAYYQAL ATEKRLEAGR RNKLGIQAMS
REEIDQANNV LQTVQHQLAK AQATRDLAKL DLDRTVIRAP ADGWVTNLNV YAGEFITRGS
TAVALVKQHS FYVLAYLEET KLEGVRPGYY VEITPLGSSR TLKGVVDSVA AGVTNASSSS
DSKGMATVDS NLEWVRLAQR VPVRIRLSEE QGNLWPAGTT ATVVITGASD PDSRQMNFMQ
KVVHRLREFG
//
