ID   A0A3N1NRU6_9GAMM        Unreviewed;       496 AA.
AC   A0A3N1NRU6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ROQ21572.1};
GN   ORFNames=EDC38_2198 {ECO:0000313|EMBL:ROQ21572.1};
OS   Marinimicrobium koreense.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC   Cellvibrionaceae; Marinimicrobium.
OX   NCBI_TaxID=306545 {ECO:0000313|EMBL:ROQ21572.1, ECO:0000313|Proteomes:UP000273643};
RN   [1] {ECO:0000313|EMBL:ROQ21572.1, ECO:0000313|Proteomes:UP000273643}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 16974 {ECO:0000313|EMBL:ROQ21572.1,
RC   ECO:0000313|Proteomes:UP000273643};
RA   Goeker M.;
RT   "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT   most valuable type-strain genomes for metagenomic binning, comparative
RT   biology and taxonomic classification.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROQ21572.1}.
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DR   EMBL; RJUK01000001; ROQ21572.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1NRU6; -.
DR   OrthoDB; 6278312at2; -.
DR   Proteomes; UP000273643; Unassembled WGS sequence.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR006905; Flavin_halogenase.
DR   InterPro; IPR033856; Trp_halogen.
DR   PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR   PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR   Pfam; PF04820; Trp_halogenase; 1.
DR   PIRSF; PIRSF011396; Trp_halogenase; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000273643}.
FT   ACT_SITE        78
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT   BINDING         78
FT                   /ligand="7-chloro-L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:58713"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         333
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT   BINDING         342
FT                   /ligand="L-tryptophan"
FT                   /ligand_id="ChEBI:CHEBI:57912"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ   SEQUENCE   496 AA;  56135 MW;  35F3B69D2B960F6D CRC64;
     MNHSIKNVLI VGGGSSGWMA AAVLARFFSK QIQIQLVESS EIGTVGVGEA TIPPIRTFND
     VLGIKEADFL KQTMGTIKLG IQFENWSQPG DSYMHAFGEI GRNLGIAGFH HYWLKARQAG
     VAEDFWRYSL NEQAARHNRF APMETIPGTQ FPGLTHAYHL DAGLYAQMLR AYSEKLGVKR
     IDGKIQTVDK DSESGDIAAV QLESGERLEA DLFIDCSGFR ALLIGEALDV DFEDWSHWLP
     CDRALAVPSE AAETITPYTR AIAHEGGWQW RIPLQHRTGN GLVYSHRHLS DDEATHTLLS
     NLDTPALADP RPIRFKTGRR VQQWCQNVVS LGLSSGFLEP LESTSLHLVQ QGLTRLIKLF
     PRNGIQPSDI EEYNRQSQIE FEKIRDFIIL HYHLNSKTDS PFWRMCREAP KPESLLRRID
     LFAGSGRVFR EQDELFSETA WEQVMIGQGI TPQDYHPLVD NLEDHQLREF MNSWQRIVDK
     TVAQMPSHND FIASLK
//