ID   A0A3N1XDA7_9BURK        Unreviewed;       394 AA.
AC   A0A3N1XDA7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 17.
DE   SubName: Full=Acetyl-CoA C-acetyltransferase {ECO:0000313|EMBL:ROR24719.1};
GN   ORFNames=EC845_0747 {ECO:0000313|EMBL:ROR24719.1};
OS   Comamonas sp. BIGb0124.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=2485130 {ECO:0000313|EMBL:ROR24719.1, ECO:0000313|Proteomes:UP000267274};
RN   [1] {ECO:0000313|EMBL:ROR24719.1, ECO:0000313|Proteomes:UP000267274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIGb0124 {ECO:0000313|EMBL:ROR24719.1,
RC   ECO:0000313|Proteomes:UP000267274};
RA   Samuel B.;
RT   "Genomic analyses of the natural microbiome of Caenorhabditis elegans.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC       {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROR24719.1}.
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DR   EMBL; RJVF01000008; ROR24719.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1XDA7; -.
DR   OrthoDB; 8558405at2; -.
DR   Proteomes; UP000267274; Unassembled WGS sequence.
DR   GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR   CDD; cd00751; thiolase; 1.
DR   Gene3D; 3.40.47.10; -; 2.
DR   InterPro; IPR002155; Thiolase.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR020610; Thiolase_AS.
DR   InterPro; IPR020617; Thiolase_C.
DR   InterPro; IPR020616; Thiolase_N.
DR   NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR   PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR   Pfam; PF02803; Thiolase_C; 1.
DR   Pfam; PF00108; Thiolase_N; 1.
DR   PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS00099; THIOLASE_3; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267274};
KW   Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ROR24719.1}.
FT   DOMAIN          7..263
FT                   /note="Thiolase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00108"
FT   DOMAIN          271..392
FT                   /note="Thiolase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02803"
FT   ACT_SITE        90
FT                   /note="Acyl-thioester intermediate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        350
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT   ACT_SITE        380
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ   SEQUENCE   394 AA;  41184 MW;  02D70E11A2CBCAF2 CRC64;
     MAKPEIVLCS PVRTAIGTYG GALKDTPATE LGAAVIRETL RRSGLAADLI DTVVMGNVIQ
     AGTKMNPARQ AAIGGGLPVQ VPALTVNRVC GSGAQAIASA ALEIAAGYAE VAIAGGMENM
     DQAPYLVPGG RWGNRMGDAQ MLDSMLRDGL NDAFSGQHSG WHTEDLVSQY GISREDQDRW
     AARSQQQFST AQAAGRFDAE IVTIELASRK GPVSFAKDEA NRPDTTLETL AKLKPAFRKD
     GTITAGNAPG LNSGAAAVIV AERSFAEKNG LKPWARLVSH GVAAVEPGMF GIGPVPAVKL
     ALERANWKHT DVERIEINEA FAAIALACLR ELELPEDIVN VEGGSIAHGH AIGATGAVLT
     TRLLHSMRRD GLTRGIVTLC IGGGQGIALA LEML
//