ID   A0A3N1XDL7_9BURK        Unreviewed;       434 AA.
AC   A0A3N1XDL7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:ROR24825.1};
GN   ORFNames=EC845_0859 {ECO:0000313|EMBL:ROR24825.1};
OS   Comamonas sp. BIGb0124.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=2485130 {ECO:0000313|EMBL:ROR24825.1, ECO:0000313|Proteomes:UP000267274};
RN   [1] {ECO:0000313|EMBL:ROR24825.1, ECO:0000313|Proteomes:UP000267274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIGb0124 {ECO:0000313|EMBL:ROR24825.1,
RC   ECO:0000313|Proteomes:UP000267274};
RA   Samuel B.;
RT   "Genomic analyses of the natural microbiome of Caenorhabditis elegans.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROR24825.1}.
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DR   EMBL; RJVF01000008; ROR24825.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1XDL7; -.
DR   OrthoDB; 9805807at2; -.
DR   Proteomes; UP000267274; Unassembled WGS sequence.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000267274}.
FT   MOD_RES         213
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   434 AA;  46557 MW;  BA5344665BF98CEA CRC64;
     MSNSDTQSGW KFETLSVHAG YSPDPTTRAV AVPIYQTAAY AFDSAQHGAD LFDLKVEGNI
     YTRIGNPTQT VLEQRLAALE GGVGALALAS GQAAVTYSIL TIAEAGDNIV SSTALYGGTY
     NLFAHTLPQF GITTRFADHR DPASFEPLID DQTKAIFVES LGNPSGTVTD IARIAEIAHR
     HGVPLIVDNT VPSPYLSRPI EHGADIVVHS LTKYLGGHGT SIGGAIVDSG KFPWAVHKTR
     FKRLNEPDVS YHGVVYTEAL GPAAYIGRAR VVPLRNTGAA ISPFNAFLIL QGIETLALRV
     DRISDNALAV AQHLRRHAAV KWVNYAALED HAEYPLVQRY LSGKASGILT FGVPGGREGG
     ARFLDALKLF TRLVNIGDVR SLATHPASTT HRQLSPEELA RTGVAEDTVR LSVGIEHIDD
     LLADLDQALA QVTR
//