ID   A0A3N1XEU6_9BURK        Unreviewed;       512 AA.
AC   A0A3N1XEU6;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 16.
DE   SubName: Full=3-hydroxybutyryl-CoA dehydrogenase {ECO:0000313|EMBL:ROR25239.1};
GN   ORFNames=EC845_1281 {ECO:0000313|EMBL:ROR25239.1};
OS   Comamonas sp. BIGb0124.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Comamonadaceae; Comamonas.
OX   NCBI_TaxID=2485130 {ECO:0000313|EMBL:ROR25239.1, ECO:0000313|Proteomes:UP000267274};
RN   [1] {ECO:0000313|EMBL:ROR25239.1, ECO:0000313|Proteomes:UP000267274}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BIGb0124 {ECO:0000313|EMBL:ROR25239.1,
RC   ECO:0000313|Proteomes:UP000267274};
RA   Samuel B.;
RT   "Genomic analyses of the natural microbiome of Caenorhabditis elegans.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; butanoate metabolism.
CC       {ECO:0000256|ARBA:ARBA00005086}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROR25239.1}.
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DR   EMBL; RJVF01000008; ROR25239.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N1XEU6; -.
DR   OrthoDB; 5287258at2; -.
DR   Proteomes; UP000267274; Unassembled WGS sequence.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   GO; GO:0044248; P:cellular catabolic process; IEA:UniProt.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:InterPro.
DR   GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR   InterPro; IPR006108; 3HC_DH_C.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48075:SF5; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR   Pfam; PF00725; 3HCDH; 2.
DR   Pfam; PF02737; 3HCDH_N; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000267274}.
FT   DOMAIN          13..190
FT                   /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT                   /evidence="ECO:0000259|Pfam:PF02737"
FT   DOMAIN          193..290
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
FT   DOMAIN          420..500
FT                   /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00725"
SQ   SEQUENCE   512 AA;  55265 MW;  59380583C975656D CRC64;
     MQTPSSSLIF SDVGIVGAGA MGRGIAQLAA QAGSRVWLYD TSSHAAEQAR TALDHQWQSL
     VAKGRLAPDA AQAYLARVSV AQDLQAFAPC TLVVEAAIER LDIKQHVFAD LERIVSAETV
     LATNTSSLPI TAIAARLKRP QRFAGYHFFN PAPLMKVVEV VRGLATEDSV CQSLADYARQ
     MGHTPVQAQD TPGFIVNHAG RGYGTEALRI VSEDVADFQT IDLILREQAG FKLGPFELMD
     LTGLDVSHPV MESIYRQYYD EPRFKPSVIT AQRLSAGLLG RKSGAGFYAY DNGQARLAPE
     PAVPEVATLP PVWVSPRAAR RPELLQLLKN LGATLETGAH ASAHALILVA PLGFDVTTLA
     AVDRLDATRT LGIDMLVSDE VTRRRVLATN PATRPDMRRA AHALFARDGK AVSVIRDSGG
     FVTQRVLATI VNIACDICQQ GICSPQDLDT AVTLGLGYPV GPLALGDRYD PSSVLEILFN
     LQTVYGDPRY RPSPWLRRRG ALGLSLLQPE AD
//