ID A0A3N1XN86_9FIRM Unreviewed; 773 AA.
AC A0A3N1XN86;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364053};
DE EC=5.6.2.4 {ECO:0000256|RuleBase:RU364053};
GN ORFNames=EDD66_10582 {ECO:0000313|EMBL:ROR28144.1};
OS Mobilisporobacter senegalensis.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC Mobilisporobacter.
OX NCBI_TaxID=1329262 {ECO:0000313|EMBL:ROR28144.1, ECO:0000313|Proteomes:UP000273083};
RN [1] {ECO:0000313|EMBL:ROR28144.1, ECO:0000313|Proteomes:UP000273083}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26537 {ECO:0000313|EMBL:ROR28144.1,
RC ECO:0000313|Proteomes:UP000273083};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618,
CC ECO:0000256|RuleBase:RU364053};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922, ECO:0000256|RuleBase:RU364053}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROR28144.1}.
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DR EMBL; RJVG01000005; ROR28144.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N1XN86; -.
DR OrthoDB; 9810135at2; -.
DR Proteomes; UP000273083; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR CDD; cd18807; SF1_C_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR005751; ATP-dep_DNA_helicase_PcrA.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01073; pcrA; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA-binding {ECO:0000256|RuleBase:RU364053};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000273083}.
FT DOMAIN 5..292
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 293..570
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 26..33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 773 AA; 88454 MW; 7F064AC0995F96AA CRC64;
MSIYDSLNKE QQKAVKHDKG PLLILAGAGS GKTRVLTHRI AYLIDELNVN PWNILALTFT
NKAANEMRER VDKIVGYGSE NIWVSTFHST CVRILRRYIE CLGYDRSFTI YDADDQKTLI
REICKFLEID TKNIKERTLL SVISSAKDEL ISPEEYELNA QGDFVKRKYA SVYKEYQKRL
KSNNALDFDD LIYKTVELFQ NNPEVLDYYQ KRFKYIMVDE YQDTNTAQFR LISILASTRN
EEGEIEHNLC VVGDDDQSIY KFRGANIYNI LNFEQQFPDT KVIKLEQNYR STQNILNAAN
EVISNNVGRK DKSLWTENEE GEPIHFTQYD NEYEEAENVV RDIDRMINDD GADYNDFAIL
YRTNAQSRIF EEKLILKNIP YKIVGGVNFY QRKEVKDLLA YLKTIDNGLD DIAVKRIINI
PKRGIGLTTI DRVTAYALNN DISFYDALRH AEYIPNLGRS AGKISSFVSL IEVLKSHLSS
PDYSLEDLMN EIIEATGYVT ELEAEETEEA QGRIDNINEL INKVVTYEKN ATEEPTLSEF
LEEVALVADI DSLEESNNVV ILMTLHSAKG LEFPYVYLCG MEDGIFPSYM CITSDDPTEV
EEERRLCYVG ITRAMKKLSL SAARQRMVRG ETQFNKPSRF LREIPRYLLK QSASSLAPRF
PKNSSMERNS FSGSSYSNKT MNSTLFDKTP YQVPKSSLHS NPYATMPKKQ FAVTNAEPLA
YGIGDRVSHF KFGTGTVSDI TQGGKDYEVT VDFDNAGVKK MLATFAKLKK ETN
//
