ID   A0A3N2APM2_9MICO        Unreviewed;       719 AA.
AC   A0A3N2APM2;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 14.
DE   SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:ROR64990.1};
GN   ORFNames=EDD26_0342 {ECO:0000313|EMBL:ROR64990.1};
OS   Agrococcus jenensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC   Agrococcus.
OX   NCBI_TaxID=46353 {ECO:0000313|EMBL:ROR64990.1, ECO:0000313|Proteomes:UP000275456};
RN   [1] {ECO:0000313|EMBL:ROR64990.1, ECO:0000313|Proteomes:UP000275456}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 9580 {ECO:0000313|EMBL:ROR64990.1,
RC   ECO:0000313|Proteomes:UP000275456};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROR64990.1}.
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DR   EMBL; RKHJ01000001; ROR64990.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N2APM2; -.
DR   OrthoDB; 2365435at2; -.
DR   Proteomes; UP000275456; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        210..233
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        286..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        379..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..565
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        572..598
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        604..624
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        645..666
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        672..692
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          567..702
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
SQ   SEQUENCE   719 AA;  73701 MW;  C31505C37A66F697 CRC64;
     MTSSHPTDRS ERRGVPRWLR VLIPAVLILG WLAAAGIGGP TFGKLSTVVS NDQTSFLPAT
     AESTEVQALL PEFLGADELP AIVVVAADAE LDASALEGVD ALQQAIAELD GVVETSPVVP
     SDDGQAAQIV ALLDASGPSS DLTGVVEELR AEVTDADLGE GVQAAVTGPA GFTADIAAAF
     EGIDGILLLV ALGAVFIILV LVYRSPLLPL LVLFTSVAAL CLAILIVFTL AQADILTLSG
     QTQGILFILV VGAATDYALL YTARFREALG QTQSRWQATL AALRGSTEPI VASGGTVIAG
     LLCLLLSDLV SNQQLGPVAA IGIATSILAG LTLLPALLLA FGRVAFWPVA PTPARPRTKP
     EDKGVWGAVA RLVDRRSRAV WIVTALVLGA GALGVTQLQA NGVPSSDFVV GESEARDGQA
     LLSAHYPGGS GSPTQVVVPE ADQDAVAEAL ADAEGVEGVA VASEDSPSGS IPLPVDPASP
     FAAAAPTVVD GQVLLQATLV AAPDSDEAQQ VVRELRDVVH GASADGIVGG PTATAIDTND
     ASQRDRALII PIVLVVISLI LMLLLRSIAA ALLLLATTVL SYGTALGVGA LILTALGIPA
     MDPSVPLFAF VFLVALGVDY NIFLMTRVRE EVGRIGHRRG VLRGLRVTGG VITSAGVVLA
     ATFAALGVIP VLFLLQLAII VALGVLIDTT LVRSLLVPAL ALEIGPNTWW PSKLGRGPR
//