ID A0A3N2DAY1_9MICO Unreviewed; 309 AA.
AC A0A3N2DAY1;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=Non-homologous end joining protein Ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN Name=ku {ECO:0000256|HAMAP-Rule:MF_01875};
GN ORFNames=EDD28_1563 {ECO:0000313|EMBL:ROR96970.1};
OS Salana multivorans.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Beutenbergiaceae;
OC Salana.
OX NCBI_TaxID=120377 {ECO:0000313|EMBL:ROR96970.1, ECO:0000313|Proteomes:UP000275356};
RN [1] {ECO:0000313|EMBL:ROR96970.1, ECO:0000313|Proteomes:UP000275356}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 13521 {ECO:0000313|EMBL:ROR96970.1,
RC ECO:0000313|Proteomes:UP000275356};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: With LigD forms a non-homologous end joining (NHEJ) DNA
CC repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds
CC linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA
CC nor ssDNA. Recruits and stimulates the ligase activity of LigD.
CC {ECO:0000256|HAMAP-Rule:MF_01875}.
CC -!- SUBUNIT: Homodimer. Interacts with LigD. {ECO:0000256|HAMAP-
CC Rule:MF_01875}.
CC -!- SIMILARITY: Belongs to the prokaryotic Ku family. {ECO:0000256|HAMAP-
CC Rule:MF_01875}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROR96970.1}.
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DR EMBL; RKHQ01000001; ROR96970.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2DAY1; -.
DR OrthoDB; 9795084at2; -.
DR Proteomes; UP000275356; Unassembled WGS sequence.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:UniProtKB-UniRule.
DR CDD; cd00789; KU_like; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR HAMAP; MF_01875; Prokaryotic_Ku; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR009187; Prok_Ku.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR NCBIfam; TIGR02772; Ku_bact; 1.
DR PANTHER; PTHR41251; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR PANTHER; PTHR41251:SF1; NON-HOMOLOGOUS END JOINING PROTEIN KU; 1.
DR Pfam; PF02735; Ku; 1.
DR PIRSF; PIRSF006493; Prok_Ku; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA repair {ECO:0000256|HAMAP-Rule:MF_01875};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01875}; Reference proteome {ECO:0000313|Proteomes:UP000275356}.
FT DOMAIN 52..181
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
FT REGION 256..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 280..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 309 AA; 33174 MW; 72A05AAF7AE0BBCC CRC64;
MRPLWSGDIA FGLVSVPVKL YSATSSHDVS FHQVHVEDGG RVRYERRCEV CGKVVSYEDI
AKAYDDEGER VIVTEDDLAT LPTAAKREIQ VLSFVPGEQV DPILFETSYY AEPAGRSPKA
YALLERVLGE TGRVAVVSFA LRGKARLGIM RVREGVLVVQ AIHWADEVRA LETDATAALA
DAPDVTAKEL AMATALVESM AGDFDPAEYP DTYTDELREL IDAKLKGGEA FATEEKQEEE
MGDVVDLVAA LRRSVEERKK AGGSGSSGST MGRAASKKPA ASTGTASTAK SSTAKTSTRK
TPAKKPKAS
//
