ID A0A3N2MAA3_9BACT Unreviewed; 1362 AA.
AC A0A3N2MAA3;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=EEL33_07790 {ECO:0000313|EMBL:ROT07063.1};
OS Muribaculaceae bacterium Isolate-037 (Harlan).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae.
OX NCBI_TaxID=2486461 {ECO:0000313|EMBL:ROT07063.1, ECO:0000313|Proteomes:UP000275399};
RN [1] {ECO:0000313|EMBL:ROT07063.1, ECO:0000313|Proteomes:UP000275399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate-037 (Harlan) {ECO:0000313|Proteomes:UP000275399};
RA Clavel T., Strowig T.;
RT "Sequence and cultivation study of Muribaculaceae reveals novel species,
RT host preference, and functional potential of this yet undescribed family.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT07063.1}.
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DR EMBL; RIAZ01000008; ROT07063.1; -; Genomic_DNA.
DR Proteomes; UP000275399; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR CDD; cd17574; REC_OmpR; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR018060; HTH_AraC.
DR InterPro; IPR018062; HTH_AraC-typ_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR011110; Reg_prop.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR011123; Y_Y_Y.
DR PANTHER; PTHR43547:SF2; HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE C; 1.
DR PANTHER; PTHR43547; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR Pfam; PF12833; HTH_18; 1.
DR Pfam; PF07494; Reg_prop; 2.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF07495; Y_Y_Y; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SMART; SM00342; HTH_ARAC; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 2.
DR SUPFAM; SSF52172; CheY-like; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
DR PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000313|EMBL:ROT07063.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553, ECO:0000256|PROSITE-
KW ProRule:PRU00169}; Reference proteome {ECO:0000313|Proteomes:UP000275399};
KW Transferase {ECO:0000313|EMBL:ROT07063.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 779..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 837..1057
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT DOMAIN 1109..1224
FT /note="Response regulatory"
FT /evidence="ECO:0000259|PROSITE:PS50110"
FT DOMAIN 1254..1353
FT /note="HTH araC/xylS-type"
FT /evidence="ECO:0000259|PROSITE:PS01124"
FT REGION 1064..1106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1157
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00169"
SQ SEQUENCE 1362 AA; 153670 MW; 845FD0C04C12B661 CRC64;
MPRKTIILSL LVILFARISC YSSDSHLELR HLDAMPGSYN NLITALHKHS GGMLWFGTSS
GLCRYDGYNV KQVNGGITDS TTILNDHILN IHEDCRGKLW LHSSDRYGVY DPVMDRLDIP
DSESIVQKFG LEGFISNLTT DANGDIWLAL SGKGLYRIRC VDDKVEKVKG IPSTFAEITD
MVIKDGELTA VDKRGALLFM DIEGMKVVST VAPDPIMNGN HLYEMYVDGD DRVWIYQMEL
LYVYDRRNGK WLNDRIPNHG KIGIMKKIFQ DSSGRLWIAR DHHGLERILT TDEGLHFVPA
DPPGMATRNN TITCFMEDSA GTIWMGTYKR GLLSHNESVR KFTLEEFPDV NCVTPASGND
MWVGTDSSGL WIWDTKTGAR RRLSDPSFGE SEPAITSLTP DGNSNLYIGS FSKGLRLYDG
KNFRKITTSS ALDDSYVWAS EFDSDGRLWC GTLGGGLFMY DPSTGEVVSY KNGTTELLSN
YVMSVVLSRD KRVYIGTSYG ISVYDPKSGK LKRFRDLFPG IDTYRWKVSQ IYEDSRGLLW
VGTSNGLKVI DRVHGKVQEI KLNDDGKQRY VLGITQDNGG SMWVSEGAML INIKVGYDEK
TGNLNVVTHA YDNRDGLMEC DFNQRSFGKL PDGEIVVGGL YGLNRFSPSE MKFNMIHPRV
VFTDLYMGSR LVRPGEEVDG RVVMKNGLAD GAEIEFSHNP KEFSIYFSTD DYALPEKTMY
EYRLEGYNDE WTFCAPGVNH VTYTNLSPGK YRLLVRAVNG DGYESEEPGE LFIRVYPPFW
TTTCAIVIYI LLGMVAIWGI VKIVSEMERR KFERDMHEEA MRKQEEINQL KFKFFTNVSH
DLRTPLSLIV SPLEEMIKES TDERQTRRLT LMRSNAMRLL TLVNQLLDFR KNEVAGLQLN
PTEGDVVAFS QNVCNSFVNL SERKNINLTF YSDRESISLM FDEDKLEKIF MNLLGNAFKF
TPAGGRVDVS LEQVGEENPV LRIKIADTGV GIKDKDKEHI FERFYQVDDD GESHPHMGSG
IGLSMVYEYV KLHDGTVRVT DNVDHGSVFI IDIPIRHIDR KSKGDVCREP KPVRQENVSV
RPENVAEAAD ANSVEGSSGE GNAVDSRPLA LVVDDNPDMT EMLKFELEDD FEVITASDGN
EALKVIENVT PAIILTDLMM PGMDGIELCR RLKGNKATVA IPIIILTAKH DLGVKLEGLT
LGADDYITKP FNFNVLKLRM KRLVELTAKG ARRSLVDPEP EAIKITPLDE QFIEKAVKYV
SDNIDSSELS VEELSEVLGM SRVRLYKKIK QITGKTPIEF IRVIRLKRAA QLLRESQLNV
SEIAYRTGFN SPKMFSKYFK EEFGILPSVY QDKEGSETNY TV
//
