ID A0A3N2MGB6_9BACT Unreviewed; 227 AA.
AC A0A3N2MGB6;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 13.
DE RecName: Full=pre-crRNA processing endonuclease {ECO:0000256|PIRNR:PIRNR029950};
DE EC=3.1.-.- {ECO:0000256|PIRNR:PIRNR029950};
GN Name=cas5c {ECO:0000313|EMBL:ROT09195.1};
GN ORFNames=EEL33_01895 {ECO:0000313|EMBL:ROT09195.1};
OS Muribaculaceae bacterium Isolate-037 (Harlan).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae.
OX NCBI_TaxID=2486461 {ECO:0000313|EMBL:ROT09195.1, ECO:0000313|Proteomes:UP000275399};
RN [1] {ECO:0000313|EMBL:ROT09195.1, ECO:0000313|Proteomes:UP000275399}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate-037 (Harlan) {ECO:0000313|Proteomes:UP000275399};
RA Clavel T., Strowig T.;
RT "Sequence and cultivation study of Muribaculaceae reveals novel species,
RT host preference, and functional potential of this yet undescribed family.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: CRISPR (clustered regularly interspaced short palindromic
CC repeat) is an adaptive immune system that provides protection against
CC mobile genetic elements (viruses, transposable elements and conjugative
CC plasmids). CRISPR clusters contain spacers, sequences complementary to
CC antecedent mobile elements, and target invading nucleic acids. CRISPR
CC clusters are transcribed and processed into CRISPR RNA (crRNA).
CC {ECO:0000256|PIRNR:PIRNR029950}.
CC -!- SIMILARITY: Belongs to the CRISPR-associated protein Cas5 family.
CC Subtype I-C/Dvulg subfamily. {ECO:0000256|PIRNR:PIRNR029950}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT09195.1}.
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DR EMBL; RIAZ01000002; ROT09195.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2MGB6; -.
DR Proteomes; UP000275399; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-UniRule.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:UniProtKB-UniRule.
DR CDD; cd09752; Cas5_I-C; 1.
DR Gene3D; 3.30.70.2660; -; 1.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR010155; CRISPR-assoc_prot_Cas5d.
DR NCBIfam; TIGR01876; cas_Cas5d; 1.
DR NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR Pfam; PF09704; Cas_Cas5d; 1.
DR PIRSF; PIRSF029950; Cas_CT1134; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118,
KW ECO:0000256|PIRNR:PIRNR029950};
KW Endonuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR029950};
KW Nuclease {ECO:0000256|PIRNR:PIRNR029950};
KW Reference proteome {ECO:0000313|Proteomes:UP000275399};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR029950}.
SQ SEQUENCE 227 AA; 26172 MW; 13E5A1DC4066DE63 CRC64;
MIYIDKEYGL EVWGDLACFT RPELKVERVS YDVITPSAAR NIFQSIFWKP AIQWRITRIE
VLNPIKHFSI RRNEVGAIGG GKADAPPIIA ADKRQQKNSL MLRDVRYRIY AVMEYVPVRD
RKGEHKHAPD ANENPAKYQS MFERRASKGQ CFNMPYLGTR ECSAYFSLLP DNSKNGEDLL
QESIDFGIML YDLDFSNPSN IIPMFYRAKM NNGVIEVPPI TSNEILR
//
