ID A0A3N2MKE9_9BACT Unreviewed; 626 AA.
AC A0A3N2MKE9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=RecQ family ATP-dependent DNA helicase {ECO:0000313|EMBL:ROT10619.1};
GN ORFNames=EEL49_02810 {ECO:0000313|EMBL:ROT10619.1};
OS Muribaculaceae bacterium Isolate-104 (HZI).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae.
OX NCBI_TaxID=2486471 {ECO:0000313|EMBL:ROT10619.1, ECO:0000313|Proteomes:UP000266993};
RN [1] {ECO:0000313|EMBL:ROT10619.1, ECO:0000313|Proteomes:UP000266993}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate-104 (HZI) {ECO:0000313|Proteomes:UP000266993};
RA Clavel T., Strowig T.;
RT "Sequence and cultivation study of Muribaculaceae reveals novel species,
RT host preference, and functional potential of this yet undescribed family.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT10619.1}.
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DR EMBL; RIBJ01000031; ROT10619.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2MKE9; -.
DR OrthoDB; 9763310at2; -.
DR Proteomes; UP000266993; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR CDD; cd17920; DEXHc_RecQ; 1.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF105; BLOOM SYNDROME PROTEIN; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ROT10619.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000266993}.
FT DOMAIN 22..190
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 214..363
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 626 AA; 70555 MW; DDB976FC9F75DF18 CRC64;
MHDVLRKYWG YDSFRPKQKE IILSVLGGND TLGLLPTGGG KSITFQVPAL VLGGVTIVVT
PLISLMKDQV DNLRQRSVPA VYLHSGLTRA EHKLAMDKCR LGKARLLYVS PEKLKSKTFV
EALRTMDVRL IAVDEAHCIS QWGYDFRPSY LEIAALRKHF PSVPVLALTA SATPEVTQDI
MERLGFDAPR VFARSFSRPN ISYIVRRAEH KESMLLKALN STSGSAIVYV RSRKRTREIA
EFLAKEGISA AHYHAGLSIE EKNERQRQWK TGEIRTIVAT NAFGMGIDKP DVRIVVHYDI
PPSLEEYYQE AGRAGRDGKP SFALVIAGNY DKGILSRRIS DAFPSRDYIK KVYELACVFL
NVPVGEGYGS ARDFDFNLFC SRFSLQPVMT RSALHLLTRA GWIEYVEEVA SRSRAMVLLG
KEELYSLRVG DDADRVLQLM LRTYTGLFAD YVNISEEVIS DRLKISRERV YQALLALGRA
HAVHYVPRSN TPYIYYTTSR EDKKYILIPT EIYERQRERM ERRINAVKSF VFDKSGCRVN
RMLEYFGEKP EQPCGKCDEC RAAAAELSAE DREAQILYLA SQPGGHTIDY IASQLSVPVA
KVIESARPLL DEGTVVLKGS TLVLPS
//
