ID   A0A3N2N875_9BACT        Unreviewed;       376 AA.
AC   A0A3N2N875;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 13.
DE   SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:ROT18647.1};
GN   ORFNames=EEL53_12075 {ECO:0000313|EMBL:ROT18647.1};
OS   Muribaculaceae bacterium Isolate-114 (HZI).
OC   Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Muribaculaceae.
OX   NCBI_TaxID=2486475 {ECO:0000313|EMBL:ROT18647.1, ECO:0000313|Proteomes:UP000273368};
RN   [1] {ECO:0000313|EMBL:ROT18647.1, ECO:0000313|Proteomes:UP000273368}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate-114 (HZI) {ECO:0000313|Proteomes:UP000273368};
RA   Clavel T., Strowig T.;
RT   "Sequence and cultivation study of Muribaculaceae reveals novel species,
RT   host preference, and functional potential of this yet undescribed family.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. {ECO:0000256|ARBA:ARBA00007637}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROT18647.1}.
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DR   EMBL; RIBN01000026; ROT18647.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N2N875; -.
DR   Proteomes; UP000273368; Unassembled WGS sequence.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009225; P:nucleotide-sugar metabolic process; IEA:InterPro.
DR   CDD; cd05246; dTDP_GD_SDR_e; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.90.25.10; UDP-galactose 4-epimerase, domain 1; 1.
DR   InterPro; IPR005888; dTDP_Gluc_deHydtase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43000:SF7; DTDP-D-GLUCOSE 4,6-DEHYDRATASE; 1.
DR   PANTHER; PTHR43000; DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000273368}.
FT   DOMAIN          4..274
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   376 AA;  43433 MW;  941AD37BF44A4922 CRC64;
     MKSILITGGA GFIGSHVVRL FVNKYPDYKI VNLDKLTYAG NLANLKDIED KPNYKFIKGD
     ISDLEEMRRI IRDNGITGII HLAAESHVDR SIKDPFTFAR TNVMGTLALL QAAKEYWESL
     PERYEGKLFY HISTDEVYGA LELTNPEGIE SPFSTTASSE HHHAYGTDFF LETTKYNPHS
     PYSASKASSD HFVRAYHDTY GMPTLVTNCS NNYGPYQFPE KLIPLFINNI RHRKPLPVYG
     KGENVRDWLF VEDHARAIDL IYHKGKVAET YNIGGFNEWK NIDIIKVVIK TVDRLLGNPE
     GYSDELITYV TDRLGHDMRY AIDSRKLQKE LGWEPSLQFE EGIEKTVKWY LDNQEWMDNI
     TSGDYERYYE DMYSKR
//