ID   A0A3N2P056_9ACTN        Unreviewed;       971 AA.
AC   A0A3N2P056;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Hsp70 family protein {ECO:0000313|EMBL:ROT28088.1};
GN   ORFNames=EF879_23020 {ECO:0000313|EMBL:ROT28088.1};
OS   Micromonospora sp. HM5-17.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=2487710 {ECO:0000313|EMBL:ROT28088.1, ECO:0000313|Proteomes:UP000281230};
RN   [1] {ECO:0000313|EMBL:ROT28088.1, ECO:0000313|Proteomes:UP000281230}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HM5-17 {ECO:0000313|EMBL:ROT28088.1,
RC   ECO:0000313|Proteomes:UP000281230};
RA   Thawai C.;
RT   "Micromonospora sp. HM5-17, a new actinomycetes isolated from a hot spring
RT   soil.";
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family.
CC       {ECO:0000256|ARBA:ARBA00007381}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROT28088.1}.
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DR   EMBL; RJWA01000009; ROT28088.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N2P056; -.
DR   OrthoDB; 3333926at2; -.
DR   Proteomes; UP000281230; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   CDD; cd10170; HSP70_NBD; 1.
DR   Gene3D; 3.30.420.40; -; 3.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR42749; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR   PANTHER; PTHR42749:SF1; CELL SHAPE-DETERMINING PROTEIN MREB; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   PRINTS; PR00301; HEATSHOCK70.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000281230};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        526..548
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          155..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          462..505
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        473..494
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   971 AA;  100317 MW;  45FAAB69D1BA4DBD CRC64;
     MEGQDGGGYG LGVDLGTSHT VAVLRWPDGR TRPLLFDGQP ILPSGVFLGP DGRLYVGRDA
     QRLAQADPAR YEPNPKRRID EPAVLLGDRE IPTAELLASV LRAVANAAVE AVGFLPPAVL
     TYPATWGARR REALAAAVAQ AGWPPVGGVA AGPVVDPDDA EPTVRLGSAP AAPAGPGSAP
     VVPAPRSAGG GTLLVPEPVA AARYFVDVLR RPVPVGSALA VFDFGGGTLD IAVVRNEGVD
     GNGRPRFAVI GSGGVPDLGG LDLDAALVQH LGTVISVAHG PVWQQLNQPV TASQWRNRRQ
     FWDDVRGAKE MLSRAATAPV PVPGIEQALH LTREELERVI TPLLRRGVFE TATVIANCRL
     TADQLAGLFL VGGSSRVPLV ARLLHAELGI APTVLEQPEL PVAEGALAEL APAVPAAGTE
     APAGVAGVAP TTGVPVSPAG GLVSGAPAGA VPVSGAPAGG YEPGRAPVAT APHPVSPGQP
     GAPGSPPPYG AAGAPAYPNG PAGGGMPPTG GAARLAGWAE LLRRRVVWLG AGAAVAVVAV
     AAAAVLYLTR DPYPALDFAP FAEVGRIATR EPDATTLLTT TGGDRAYVGY QRSDNRLDVA
     VVDPTTAKVA RWFTTDETAE RWLWLQALPK ALIVRGGATS SSDPGVLVGF DPDTGKKLWS
     RQISGGAEAH SYDEYVVLLD RDADAVIGIN ARTGREWSLP SPKGEFGSDS AVEPVHTPGE
     YGGTADAYGN HMLPNRGKEP GLVEVGADGS VRLIDVAAGK VLKERANAAD TDDLLLAYEG
     ELFVAPKSGG YGLARFDLRT LGTPTTVYTA PDKSRQPVDL LPCGEHQVCV LETAGTDSAT
     AQLVAVRTDK AEVAWRRDVP KGERLRAVGQ NIVVQTTSSG TTVRLFTPDG RKVLEREGVA
     SRINGGNLLL FDDALSTYPG TMSVAGVVAK SGRLTQLGPL KEVVGTSCSW TTSVLICAGR
     SEFVLTRFVA E
//