ID A0A3N2P747_9ACTN Unreviewed; 735 AA.
AC A0A3N2P747;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Squalene--hopene cyclase {ECO:0000313|EMBL:ROT29776.1};
DE EC=5.4.99.17 {ECO:0000313|EMBL:ROT29776.1};
GN Name=shc {ECO:0000313|EMBL:ROT29776.1};
GN ORFNames=EF879_19355 {ECO:0000313|EMBL:ROT29776.1};
OS Micromonospora sp. HM5-17.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=2487710 {ECO:0000313|EMBL:ROT29776.1, ECO:0000313|Proteomes:UP000281230};
RN [1] {ECO:0000313|EMBL:ROT29776.1, ECO:0000313|Proteomes:UP000281230}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM5-17 {ECO:0000313|EMBL:ROT29776.1,
RC ECO:0000313|Proteomes:UP000281230};
RA Thawai C.;
RT "Micromonospora sp. HM5-17, a new actinomycetes isolated from a hot spring
RT soil.";
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004999}.
CC -!- SIMILARITY: Belongs to the terpene synthase family.
CC {ECO:0000256|ARBA:ARBA00006333}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ROT29776.1}.
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DR EMBL; RJWA01000006; ROT29776.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2P747; -.
DR OrthoDB; 9758578at2; -.
DR UniPathway; UPA00337; -.
DR Proteomes; UP000281230; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0051007; F:squalene-hopene cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR InterPro; IPR006400; Hopene-cyclase.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01507; hopene_cyclase; 1.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:ROT29776.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000281230};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 44..324
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 338..650
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 735 AA; 79622 MW; 76CE5DB7EF3A8517 CRC64;
MSGLLSPGGA PAGPETGGHP EASETRRTAG IPAPLWDQAR AALDRARDLL LSRQQPEGWW
QGELETNVTM EAEDLLLREF LGIRTPEVTE PTARWIRSKQ GADGAWATFY GGPGDPSTTI
EAYAALRLAG DPPEAEHLRR ARQFILAHGG IERSRVFTRI WLALFGEWSW HRLPAIPPEV
VFLPPRFPLN VYDFACWARQ TIVPLAIVRS LRPVRPLGFS LRELRTGQRP ERPPSLRRRA
GWMHRLDAAL RRYERHPIGP VRRTALRRAA EWVIARQEAD GSWGGIQPPW VYSLIALHLL
GYPLSHPVLK AGLAGLERFT VHEETPDGPV RRLEACQSPV WDTALAVTAL ADAGVSAGHP
ALDRAARWLL AEEIRVPGDW AVRRPGLAPG GWAFEFDNDG YPDTDDTAEV LLALRRTGAD
PAVRAAVARG VAWLRGMQSA DGGWGAFDVD NTRAIARDLP FCDFGEVIDP PSADVTAHVV
EALCAEGLAD SAAVRRGVAW LRRHQEADGS WFGRWGANHV YGTGAVVPAL IAAGVPRDDP
AVVRAVCWLH RRQNPDGGWG EDMRSYRDPS WRGRGVSTAS QTAWALLALH AARTDDIGSV
SRGLRWLVET QRPDGGWDEP QYTGTGFPGD FYINYHLYRL VFPVSALGRL LADPGWPGVV
PAAPAELTAE VGPAAPAEPT GAVGPTGAAQ LATRAEATAR TELADRVAPA GGSDGGAGPA
GGRGRTELVD QGESS
//
