ID A0A3N2PR73_9PEZI Unreviewed; 1940 AA.
AC A0A3N2PR73;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=SODALDRAFT_281380 {ECO:0000313|EMBL:ROT36978.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT36978.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT36978.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT36978.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
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DR EMBL; ML119058; ROT36978.1; -; Genomic_DNA.
DR STRING; 1314773.A0A3N2PR73; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000272025};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1370..1556
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1660..1924
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1940 AA; 216211 MW; 68446DE42A977610 CRC64;
MSRDIRQRAL QKIAALSAAS STTSFDRSDL DRLARACHTT SRLSPVTNGH CSKQSSSLGR
VPMTIREFEV LLALCKAAPA VRTGQSAQRL AHQLAPYIRE AHVQVFVPSP FFKKVEPSPT
EAFAFHVTAA LLSLGSNFHD LEESVSDSIW AFINAWGHLA GAVLPANSDD SEDPSLEDAI
QTATLAVSLI GFLDAASAQA DFWKAGGRLA LIQRISGLLS EPFLIAVETA FSTIRHAHST
DRQTKEWKRY VRHYSASGRP LGAMLLQRSV MWLLVAGTSL LVTEPTLLKK THILDLLLTG
KKDLRPSSPR NRDVDLRSLD FYATMAMDQM NYLEASADFI KLGSPLDQKL AFTVKSAALI
SYLNCLLLNE DAADADLLMT WLEEALGDPL QMADGVLASV ILKTLALICV ISPTYATSVS
RLLPRFIVQA GPDSETVAIA SKCLAHVLQR LSHDAVITTL YTLGNVLSPG SDRTLTSGAN
GGDMTADGLG AVYLGRHSAG SSISLQVHGK EETSVVWKNV IQAVCGIAAA CDDEMITALA
QSMLLQKLDK IDPAIDARII TGAAALALKG GQLEFRSLLK LYSKMSHTGV VENRTFLLDA
VMKARVRLST NLRRGSPLYD IYWEHLLESI LSIGDVHRSH QIKESDLQLA AQEIAQLLRP
LAVLMSTNDL AFNSSSDDES HAMLRDVWFN IVVHGLAAQT DLGRQYLDEL RLMAIHSPPL
VTEQRGEQIE SDIELNTVLR RGMSSEREAL QKKQLINLVP TKAGDIKGLS YRKVIFLQSA
YLVESLRADS GDCTKVMSYF LEPSMHRNDV HNTMEEVAAA VVDRYLRKTL AGNDSSFSAQ
YAAAQLATIF CNCCHRIERV QQAAFVCADR IIKEVPSALC HRSSLFALLE LLSLMWSSCV
EAETDMYSPR SNFTSTLGDV WVALSDDYDF RRHTLDALYR KAKQWVSGVI ATAPLDVKGL
LQTYLSEFND GGAYGHISLG RSFALELASL IPFTDHKMQS LDPVGSCNIN DASDFVAQYT
TRQEYRYGET LPDRGTELVS FMHLNRSASF TQSSVSSASE STNAATALAH VEARLKSKKA
AGLGEVRDIL RRAAALLCRT NRDESDVAHY LVSIPFTMFT RESVKLGVSL WLGVINENPR
LEPRLLSEIA QQWEFTIQRG LGLFSRELAH PDPFYLRKEL APSDLEGIAR HKQHVHDVLS
PHMRLIQFFG SHFNATRLGS PDIQRIFLRL LDFTLQAIRT STSHPMAREL RYQIVLFGLK
VLRFCTTIGL VAQLRLKDQL LSAGLSWFKA APRWSYGSNN LQLKTELRLL SDVAAALKQV
SHIATDSTGN TRSLQAREQL LQLLIENEYN RLSVWVHPLE PHKAHTLGHN PHKTSVENAI
APLVRTAWAE DPAIAIELAT IFQMPRIHKE VRWLLLNFPA IAVSDPEALP ILLDGALPED
VSFQLKYLLF WAPVNPATAA TYFLPAYRNN PYMIQYAMRA LESHSTDVAF FYVPQIVQTL
RYDALGYVER YILETAQFSQ LFAHQIIWNM KANAYRDDDG TIPDDIKPTL DTVMEKMVSS
FSDVDRDFYE REFAFFDEVT SISGKLKPFI KRPKPEKKQK IEEELRKIKV EVGVYLPISS
DGVVIGIDRK SGKPLQSHAK APYMATFRVK KNKAGSAQGE NMLEEAGKSG NQPKDDQTIE
VWQSAIFKVG DDCRQDVLVL QMISAFRGIF HNVGLEVFVY PYRVTATAPG CGVIEVLPNS
ISRDMLGREA VNGLYDYFIS KYGNEDSLRF QKARNNFVKS MAAYSIISFL LQFKDRHNGN
IMIDDAGHIV HIDFGFCFDI APGGIKFERA PFKLTAEMMA VMGGSTDHQT FQWFEELCVK
AFLASRQYCE KLSQIVLLMM GSGLPCFKPE SVKHFKERFV LERSEREAAG FIRDLIRKSA
DNYWTGIYDQ FQLLTNGIPY
//
