ID A0A3N2PRF5_9PEZI Unreviewed; 1549 AA.
AC A0A3N2PRF5;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=SODALDRAFT_360750 {ECO:0000313|EMBL:ROT37075.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT37075.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT37075.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT37075.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; ML119057; ROT37075.1; -; Genomic_DNA.
DR STRING; 1314773.A0A3N2PRF5; -.
DR OrthoDB; 1630at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF6; NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 2.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000272025};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1074..1366
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 1369..1500
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 298..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..1030
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 904..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 942..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 960..974
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 996..1016
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1102
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1549 AA; 172938 MW; 4AECF8BCDE9B6CA8 CRC64;
MHLFGPRNRL FACVEVRTII SREWCERLVG GGKAFCRGSS LRRSIGTPTQ IAAFSKCEYY
SFQIIYSYGV RDSIVTPTRA FHSLALALGP SFPDPFGPSL GPGTRNLFHI ILNNQFFRII
FDSSPLLLQF LQSLQFLLLL HPLNPVACLV WTQVLRDSRA RHLANKTLGP QRSAIIIVPT
PFALQSHAPF SRLLESFLVL TSFGSDFLFL LRSQPNGAAL IPSSVLLPHP NMPPRRPPGD
GGLGSPKCLL TLAVLLFTYL PLAEAQQQQR RADAQPLAQV QPDDLARHIL PAADRQWLHP
SDASKGDDHT GHPIILSGEE RAVIEKKTTE RSQDRNRDGD RIINRNDKRN HNIHLEIPNR
HDINYIKNNN TPNQNDARAV ATLAPAQSVR APPSSHRLIT RPDTGSGSGI STQPGARSLG
EWEVEDFVLL ATVDGDLYAS DRQTGTVRWH LEVDQPMVET VHHRLNTSEL DDDHHPVDHY
VWAVEPTRDG SLYIWMPGAP DPAILPTGLT MKSLVEELSP LANDNPPVIY TGTKKTTMIT
IDASTGRVLK WFGSSGSHVN EEESCLRPSG IYDFDREECS STGTITLGRT EYEVAISRKD
GRAIANLRYA EWTPNNFDRD LMSTYRRTLD NRYHSSRHDG GVYAFDLDAS DERLIFADKF
DSPVARVFDV CRPWGVTPDQ NPDLLVLPQP IPPPQNDDVA RLRSSHVFLN QTGAGSWYAL
SGLSYPLIVD APPALTSLRQ WLELDRPWGL LTQNQKSAAM IGRHSFDSVR EKGPQYYPPT
LPGGSVSQPV DDHENDSTLP TLVPDDLDGP TIVAKVRSIP QQAANSFVDL FKNPVLISIL
VLSFFFYHKD LIRWSKAKSR KFLLQREQWS KPGDLVSADL ALGSSVHAEV PALDPRTDDT
PEEKAQQQQV QQQQQQQQQQ QQQQQQLVEP SAVDEHTTAV PERTENSGLS EKSNSGQAPS
PSSTPPPPPD LAASPAKPAA KIDAENSAAG PPEKKKGKAH RGRRGGVKHR KNGPKKRDIS
TSRDDEPAAT TVEDAVKNAK RLGNSPKLEP DVVTITNDMQ SVTGPVFKLG SIEVDMEHQL
GTGSNGTLVF AGRFDGREVA VKRMLIQFYD IASQETRLLR ESDDHPNVIR YYAQEARDGF
LYIALERCAA SLADVVERPS RFPQLAQAGR ADLPAVLYQI ANGINHLHSL RIVHRDLKPQ
NILVNMDKGG RARLLVSDFG LCKKLEGGQS SFGATTGRAA GTTGWRAPEL LLDDDKDPLT
DASINSGSGT PLVNSDLLPN RRATRSIDIF SLGLVFFYVL SNGQHPFDCG DRYMREVNIR
KGNHNLSPLS VLGDYASEAK DLIRTMLDSN PKARPTTHDV MSHPFFWSAK KRLAFLCDVS
DHFEKEPRDP PSEPLLKLEE YAPIATKGDF LRHLPREFVD SLGKQRKYTG TRLLDLLRAL
RNKRNHYEDM SDSLKRTVGP LPEGYLSFWT VRFPELLLAC WNVVWELRFR SKFYQSPLSI
WRETKRPRIY LDSTLPGFVI QGISPDDTLN NALQSRWHSF RDHRSTQFS
//
