ID A0A3N2PS76_9PEZI Unreviewed; 386 AA.
AC A0A3N2PS76;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 9.
DE SubName: Full=3-beta hydroxysteroid dehydrogenase/isomerase {ECO:0000313|EMBL:ROT37284.1};
GN ORFNames=SODALDRAFT_334370 {ECO:0000313|EMBL:ROT37284.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT37284.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT37284.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT37284.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004406}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004406}.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; ML119057; ROT37284.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2PS76; -.
DR STRING; 1314773.A0A3N2PS76; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000313|EMBL:ROT37284.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000272025}.
FT DOMAIN 19..299
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 386 AA; 42593 MW; 322CCDEEE7BB9019 CRC64;
MSEKPVTTAQ KARELGRVLV IGGNGFLGHH IVNQILDDPL WAASHLSVID LRCTRNRRPD
TDKVAYYEAN ISDAEKVHSI LEQVKPDVVI HTASPAPQGD DDIAKDLFKR VNVDGTAAVI
AACQQAGVKA LVYTSSASVV TDNSSNTINA DERWPLVRGD MQPEYYTETK AAAEELVLAA
NRKDPHPTFL TTAIRPAGIF GEGDGMVTHQ LIKIYRQRRT GFQIGDGENL FDFTYVGNVA
HAHLLAARLL LVTHRAGASS IPLDYERVDG EAFFVTNDSP VYFWDFARAV WRAAGSDKGT
GHVWAMSKEL GLVLGFCSEV FFHILGKPPT FTRQRCTYSC MTRYYNISKA KRVLGYQPIV
SLDDGIKRGV RWFLEQEAAG LVPAAK
//
