ID A0A3N2PWC4_9PEZI Unreviewed; 5151 AA.
AC A0A3N2PWC4;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=SODALDRAFT_378944 {ECO:0000313|EMBL:ROT38784.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT38784.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT38784.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT38784.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; ML119055; ROT38784.1; -; Genomic_DNA.
DR STRING; 1314773.A0A3N2PWC4; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 1.
DR SMART; SM00382; AAA; 6.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000272025}.
FT DOMAIN 4932..5142
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 772..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1374..1400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3695..3732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4231..4262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4274..4827
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3143..3174
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 3701..3730
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4274..4290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4291..4344
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4363..4384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4385..4421
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4453..4472
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4480..4533
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4538..4563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4601..4631
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4632..4704
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4726..4741
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4768..4808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4809..4827
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5151 AA; 570920 MW; 4BD56624E06C7F35 CRC64;
MASIDVSSQR ATLLTDEITL EQLPAELLVV IRDHASTNLL DAVSQAALIP KLTGRIFAHF
EQVFPDICAR WILNAPRLGS RVDILASFAR VLRFAPYLST FIRSYLNNGS SSSTIPDGGR
GPHTRPLQYP DAASLHRFEP SQLLGLLLAV WRLASFDLRR YSGLLPPSEL QPLFKHQDHA
VRYLAVRIFC LQTHAADAKL EALIREHIGT TAPILGDFDG DEIDYGFLSL HEHARAEKIL
DLRRKAQDAT LGDPVSVQLV PPQGLTSLVA CYGRVMLPRT SASTTHSPSS LVMTPTTASN
MENLAAALLN DTRPILLSGL PGSGKTSLIQ QFAKDFAKHS EMVTLHINEQ TDAKMLVGLY
SADSKPGSFQ WRPGVLTTAV REGRWVLIED LDRAPNEVIS TLLPLIERGQ LLIPSRGETI
EAADGFRLFA TVRTTRGMHG RETLPNLLGL RFWQQLPIQA PAETELLDII VGTYPVLRKF
APDILSVYRR LTHAATATGA ARHSFGRSIL DRQPSSRDLL RWCRRLAGLL LTDADGKTGE
EPVTETMRDW MFMEAVDCFV CRIPDAKARE YLVLQIAQEW HMSKERVLHY LEAHIPPLED
GPDQFHIGRV RLRKNKKNKD RLGKLAKKSQ SPRPFANTTH AKKLLEQAAA AVRSGEPVLL
VGETGIGKTT VIQQLADTLG HRLVAVNLSQ QSEVGDLLGG FKPVNVRSLA VPLKEEFEDL
FSATGISTTK NQPYLERLGK TFARGDWAKV SKQWREAPKM FAKIVDELAK REAEQKREAE
QKRANLNGDG GDGGGGDGND QPAKRRKTES KLQRLLDLRP RWHAFSRNLD QFDVQVSGHS
GPFAFSFVQG NIVKAARNGD WVLLDEINLA SPDTLESIAT LLAGPSETPS ILLSETGEIE
RVKAHPNFRI FGAMNPATDV GKRDLPIGIR SRFTEIYVDS PDKDVKDLLT IVKTYLKGSG
TRDDKAADDI ARLYLDTKMR AEEKRLVDGA NEVPHFSLRT LTRVLSYVNH MAAFYGLRRA
LYEGFSMGFL TLLNRESEKI LMPLIDHRLF GQVANPQSLL SQPPKRPNDG RKYVRFVNKA
KDRHYWLCQG DLEPVERPDY IITPYVERNL LNLVRATSTR RFPILIQGPT SAGKTSMIEY
LANFTGNKFV RINNHEHTDL QEYLGTYISD SSGKLRFQEG LLVQAMRRGH WIVLDELNLA
PTDVLEALNR LLDDNRELLI PETQEVVRPH ENFMLFATQN PPGLYGGRKA LSRAFRNRFL
ELHYDDIPEE ELEYILQQRS RNTSPSDCRR IVTVYKDLSR LRQTTRMFEQ KDSFATLRDL
FRWTQRDADT REQIAAHGFM LLAERVRVPE ERVAVKEVIE KVFKVKMDTD KLYAPTALPG
KPDAKQNNDD NNDNNNDNTH GVVWTGAMRR LYILVDSALR NNEPVLLVGD TGCGKTTVCQ
MLAEARGREL HIVNAHQNTE TGDLIGSQRP VRNRGAIAEA LRTELAGVLH GVGQPSSSGS
LEELLERYHG LPAEAASAID ASIRERIASL ETRSKALFEW ADGSLVHAMK SGAFFLLDEI
SLADDSVLER LNSVLEPQRT LLLAEKGIDN SFVTATEGFQ FLATMNPGGD FGKKELSPAL
RNRFTEIWVP SLSETEDVLE IVLSKLDGDL KSFGKTIVEF SSWFARAFRS STSAGYSIRD
ILLWVKFINH FGHADADFAV VHGAATVFVD TLGANPSALV AMDPETMEAQ RQKCLDKLSE
LLRCDASAIY RAQPEVSLEP GKLSIGRFEV AREAGLAADP TFALHAPTTK RNAMRVLRSL
QMQKPILLEG SPGVGKTTLV AALATTCGRP LTRINLSDQT DLMDLFGTDM PVEGAEAGNF
AWRDAPFLQA MQRGEWVLLD EMNLASQSVL EGLNACLDHR GEVYVSELDQ VFQKHPDFRL
FAAQNPHHQG GGRKGLPSSF VNRFIVVYAD VFTEEDLLLI AGHNHPDIPH DMVQGVIRFV
SSLNHRVAVE KAFGAHGSPW EFNLRDILRW LDLMASRDAL LRTGSVDDFL GLVVRQRFRS
VQDREQVDAL YAEVFGRRPR DHSLYHDVSA AVFQVGNALL PRSRLSQPLQ PPGIDAVRRL
PELESLMICV KQGIPCILSG SSGSGKSVLL QHVAAVAGKS LVVFPLNADI DTMDLVGGFE
QSDPLRQVNA SLRSLYDGLE RSILSQLPGE VPREALSLFY ALHCCCRDGG DAPSLDGLAA
SMRAVLSMVA PESEMSSLLS AALAALAKPR VANDPRFEWL DGVIIRALET GQWLVLDNAN
LCNASVLDRL NSLLEPNGVL SINEHCGPDG APRIITPHPE FRIFLTVDPR YGELSRAMRN
RAVEIHLGDL SLPPTEMADV TSARTAEVES SLRRFRLSRD ISMASRRRNS GCAPDVSALT
LGNLSLNDAS VARRYVGVTA RVFPDGPAFS LATYQMQLDE LVFYLEAEET AGVRKATLEL
YGELSRTGFQ GIAEAQPLSP LQNAPIVRIL QQTAGDLPFW LDSCIDFLSD LHRYQGAMEI
HTRGAKAGKL ASLSRLQRSV LSDRIAAVAK DSTAGVAKFL TAVLQGAMRF LQAHLKSSTY
WKEQTYIIRA MLDFWWRTFE FVSRPASEPF EEARFQAHLG HGIKAVESLL SSVETDLNRD
LAAGFLQAIR DAFTTGFMLK TGLSMEILWR LFKPAPILSA ETLNQSRELV RLADRFDGLR
WKVRTSVSDL ANAMSTLVAA AQVVQSNPST ATQLIDDLSK EIDLLEGSIG SVSKEREISP
FFVEAFKNLE QALVLQAISS SAQDESESVI SSTDLMPLAV MSNQPTLDQI RLRGAVNKAQ
RLLSTGRLAS RDTASHAWHG KLASTLLARS KSMGAASLGS LRLLEAELPL LGRFLVKSSR
QITDSPIMAL NRTLRQLVLE VVVSAHGLGL GVHGNMEEVY HRVRSGHAAS AGLPDLTPEA
FTRLSAQYHQ TVVTEEWPTH VAAVAKDHLI PSMIAVAISD SYATIDDDES GEPGEPAPAP
APALARYARN AAAFSSVAWV QFAVGYIKLY VPDKSFDPQL RPQFEKEVYD ETKTRLQHRL
SSLLAFESHF TGQDHSLRAQ LVKEDIEALG PAPAAGQVVH YRPSQSELGQ MQADFNNVLK
SVVDMGVAST HLRRALTDSD SSAAEQELEL DLVKQNVNQL IDRLSRRFDA YQDMVTPAVD
ALHCLQLGLS LTVGLDSLVR DELATGPLMD LVPFLGGRLP DPNTALSGRS LQFLHYMGLV
VSVEGLPGIS AAQRQVLFES IHGFFSDWSK KLEADRQLEA SRTSLYRFRG SFEDEEEQDE
AEFNELFPTF DEENEEEDTK LSTEQRGRVR VRDLSVKMSE LHRNIFLKPQ EPSQSLRESC
VAISREAASE ASEKAAVGQR LNRRILPMAM WSLYEGQAAL DVNAVGGRYN FYSDPNLPAV
RQLVSLIGKI EARFRDLQSV DEIGFMQPLA DVLSACENLL SIVHTEPLAK ILPKLEHLHN
IVYEWQHGGY APSIYGAPVL YSSLTDTIIS WRREELKTWA KLFDLEVQKC RDDANSWFFM
AYQVVIAVPL TFVGSDDDPV PPLRDYAVRL VKELEVYFSS SIVGQFAGRL SLLKQLQKHL
ELLVMDYPSL SVIQDALRNF IAFYGRFEAV IDESITQARA PIEKNVKNTV LLASWKDTNI
NALRESARKS HRNLFKLVRK FRAVLGQPAA PIISRGLPDK EPVTASEEGG RHLVGGKTKT
KTDTDTDTET QGRAISRCQD AAPEWLQTNR RLSNLPKTLS VMSGMTGVVG VKNKSSWDAS
RETKSFFASL VSSIAELRKE TPEYLTEENK DQVKHLKTRK RYLFADVLKT MRQMGFRHNL
SLEALAKQES VATVLGSTPA YGHYHHCHHD DAAEHYFHKA VDIVAAARVA GHNHHDELTG
AEVARSLGYL EGMVQVLLGQ RSALVAAQRS LDSLTDSLVS ARELSNCWDD DNAIILERRP
SNLPRVVRWI IPVLEFGTRL VEAHGKLLGG VDNTEITRAL ETRAAAFRAD VEKRNDLVAV
PGKLKLARRE SLDAEARLGL QQCAQELDAM AASRPDLGFL LQQIKAWTKL TVLQEEEEEE
EEEDAQDVKL GVDDTDKFGR QVATLCDSVL VAVQEYKQAA SALLPESPRT PGWLSGSSNA
LGAMLKALRM DTITRAVQDC MAAMERLHLE TPRVRKVSTS MLGVALPILE HYAVACQHAA
RRLRALHFAT GEMTHHLGRT FAQLASKGFC TPQEKSDETQ GESGKLESGT GLGEGEGAED
ISKDIQPDED LSELAQEPNK DPNGEEMQDE KDAVDMADED MEGELGSVEG AEDEDEKDDD
GKGEENEEEE EDDMEEEAGE VDDLDPTAVD EKMWDGENEE EAEKDQQGDK AKGQKKKDEQ
MAAEGQEAND EGDEPQEAGD DQGDEPDANE DQDSAAEQEE DVRFEEDIKQ DQNVQQEDAL
ALPEAMELDL QDGESGSSDD GLDDDLSDMG DNKDDDLPEQ QASDVEDDDE PEKGEQGGES
EEANEEVDNM AGDEADDEPQ PDPEEEGQDE GSQPDKPDED QQQQQQQQHE PQQNDTANAN
AENAAPSDVK GGGLDQNNAD SMDLDDEFSN NAAQRDEGDA GDGSAQQQQQ ASAGQDGTVS
RSAQEAQPQP QSSEKKDNDD DDAQDAARRD PFKKLGDALE RWHRRQADIL EADKEQEDTK
EPKQEIEADG EGDMSRREFQ HLQNDDAAAD TQALGGASED QVQPIDDTMA IDDEDEDPSS
RVMPEEDGGE DQVGDDNNNN NNKMDMDGPE DAGQDQDKKN QGLEREDARS GVKTRQGAYD
RESPSPEDGI PGEEDEEKNE TDPDEDANAI EETSAQLSET HLADDQGGSP LRDFSEAMQL
WSDFQNKTHP LSLSLTSQLR LILTPSQSTK LSGSFRTGKR LNIKKIIPYI ASSYKRDKIW
MRRAVPTKRS YQILLCVDDS RSMGETASGT LALESLVMVS RALAMLEVGQ VGVLGFGADV
FTAHHLADPF AAHDAGARVL QRFRFDQDRT DVALLLRRTI DAFRDARARN PAASAASAAG
VDLWQLALVL SDGLTPSSAH DAIRRLLREA MEERIMVVFI VMDDSQHRKG DSVLDLKEAR
FVKDAEGNSQ VVIERYLDTF PFQYYLIVHN LEDLPNALAG LLRTWFAEVN S
//
