ID A0A3N2Q537_9PEZI Unreviewed; 1042 AA.
AC A0A3N2Q537;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=DUF221-domain-containing protein {ECO:0000313|EMBL:ROT41768.1};
GN ORFNames=SODALDRAFT_308796 {ECO:0000313|EMBL:ROT41768.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT41768.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT41768.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT41768.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; ML119052; ROT41768.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N2Q537; -.
DR OrthoDB; 1330110at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR PANTHER; PTHR13018:SF154; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000272025};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 38..59
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 123..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 167..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 396..419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 439..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 601..628
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..676
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..186
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 210..379
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 390..672
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT REGION 278..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..1042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..918
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1042 AA; 116673 MW; 334CDB2EC72E7C77 CRC64;
MDGRLGAIFG RRQQHDAGQI LLELLEDPFS SQIVSTSFWA ALGTSLGFTA GIALAFSFLR
PYNQAVYAPK LKHADEKHAP PPLGRRPWSW LPPLWSTSEY DLIQNAGMDA AIFLRFIGML
RNMFLVLSLF VLAVLIPVNL TQADEIGSGR TWIARLTPAL VWGEGQWSQV AIAYIMNTTV
MFFLWWNYRK VLHLRRRYFE SEEYQNSLHS RTLMMYDIPK ERCSDEGIAR TIDEIVPNSS
FSRTAIARNV KDLPKLIAEH DRIVRKLESV LAKYMKNPDQ LPPERPTCRP SKKDPAYETY
PSDQKVDAIE YLTNRIKQLE VEIKEVRKTV DKRSTMPYGF ASYADITEAH NIAYACRKKH
PVGATIRLAP RPNDIIWNNL PLDASTRSRR RVINNLWILL LTVVWIVPNA MIAIFLVNLS
NLGRVFPDFQ PVLEGNPTLW GFVQGILSPA ITSLVFLVLP TIFRRLSMKA GDQTKTGRER
HVLGKLYAFF VFNNLVVFSL FGSAWKFVAG VINRTNKGED AWRAIQEEDI GSTLFIALCD
ISPFFVSWLL QRQLGAAIDL AQLWTLIYSF FVRKFSSPTP RELIELTAPP TFNYASYYNY
FLFYTTIALC FAGIQPLAIP AVALYFGIDV WLKKYLLMYI FVTKNESGGM FWRALFNRVV
FATVLGDLVF FLTTWVRGEG FIRRHALTVA PLPFVMILFK FLCARQFDDK AKYYSTRNVA
KHPEESMKDH RLRSERLASR FGHPALYKPL ITPMVHQKAQ ATLHIVYKGR VSDGRDAGGA
ADDIMSVSGY SDMYALDAMA AGKPGKQAQA AGVPGFEFVS EAQMDFEYYK NRPEFADEYG
GTQGDQLGGR NLDLMRPGSP GSAAEGGDSD YSRPGTPTTT VAGGMTGRRV LQKASTDNFT
AYRPPHSTSG YNSGRSSPGI VSPAPFVPAQ LGTPMGTDRT RSPLYGLNNS SETALVQDAA
RMGTVTPAYG MAAAGRREPS VDSYRRQNTT TPGPSTGALG GGPQGYSGLP QVEFGESPSE
LQDPTQVDYF RHGRPRRQGS GW
//
