ID A0A3N2Q9A2_9PEZI Unreviewed; 2575 AA.
AC A0A3N2Q9A2;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=GTPase-activator protein for ras-like GTPase {ECO:0000313|EMBL:ROT43351.1};
GN ORFNames=SODALDRAFT_327542 {ECO:0000313|EMBL:ROT43351.1};
OS Sodiomyces alkalinus F11.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Glomerellales; Plectosphaerellaceae; Sodiomyces.
OX NCBI_TaxID=1314773 {ECO:0000313|EMBL:ROT43351.1, ECO:0000313|Proteomes:UP000272025};
RN [1] {ECO:0000313|EMBL:ROT43351.1, ECO:0000313|Proteomes:UP000272025}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F11 {ECO:0000313|EMBL:ROT43351.1,
RC ECO:0000313|Proteomes:UP000272025};
RX PubMed=30368956; DOI=10.1111/mec.14912;
RA Grum-Grzhimaylo A.A., Falkoski D.L., van den Heuvel J.,
RA Valero-Jimenez C.A., Min B., Choi I.G., Lipzen A., Daum C.G., Aanen D.K.,
RA Tsang A., Henrissat B., Bilanenko E.N., de Vries R.P., van Kan J.A.L.,
RA Grigoriev I.V., Debets A.J.M.;
RT "The obligate alkalophilic soda-lake fungus Sodiomyces alkalinus has
RT shifted to a protein diet.";
RL Mol. Ecol. 27:4808-4819(2018).
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DR EMBL; ML119051; ROT43351.1; -; Genomic_DNA.
DR STRING; 1314773.A0A3N2Q9A2; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000272025; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR CDD; cd05392; RasGAP_Neurofibromin_like; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF150; INHIBITORY REGULATOR PROTEIN IRA1-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000272025}.
FT DOMAIN 1210..1403
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 104..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 173..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2575 AA; 285943 MW; 55FD95ABEB5E0F7F CRC64;
MDSDTSLVGC LVDRIAARLP HRTGSNCREL EKDDIVVSTR STLIAISVNC ISSVLESLAA
LLEDLARSHK SQASHPTHIV VSEVYVLALA ANCCITHWDA VKTQGSTGPT KSSDARTSSS
LPTPGPLADG LVSRYLDIIA CLLEPIPDTF LLSPKTILNQ TTTRPDQFAS LVAEEQPSNQ
SVATTADSQD GDPGAHAATL EDQARIIVEY LTASSWDSSF EYFKNVIYDI RTAGASHHGT
GHGHGHGHGQ GVVSSEEDRH ALVALRLLAF FWVDGQKLGF VIKELCSSFL HFRRPYQITI
AAVVPVLITN WLNRYPQQFV QQHTQHIRLD GGADTLFDMT HAMGDQGRRK GMSFALQTTL
LFLLPDVFEV ASNLREAKSS SMAKKTAFLD TLRKALRNRN EAAAYSFITL LRAARHFDAE
DDSALVSFAL DIQDEVKDAV FRRSPLNAES PLFEQDLLTA TFVSLAQLNL DGCVDALVES
CLTPTAPHSF KAAVVQGCGY LARQSDSQRY ERLFSAVLPY VLDQLKVAAG QALEVLALDT
GAQDRDPEGT KMICLILDFL DASPKSLLAE RNVGDGKTSS GIPGSEAFEA FLSLILSTNA
TIRTHASPVT KRLFSEPWVL EELRSRGLLK SRAIRNKFWS RSCRVLSLLC DRVISGGGSM
AVREVYEYLS TRVALFSCLP ELAEVPDIPE LATVASKYET TLLVALCSPD IETCQMVTSL
IARSIEASPP DARRAEAGKV LAPLYRNQGI FDELASTTFR FTGLVAFQKR MRGLLRGLQH
PTAGILASWD HAFERWLHLS REVSSAPVNS VEEKTFAEWR NHSGFLASLG GICVTNQAAL
LEDPTLGGLK WIDKPSESHE EAPLSRYLKL SIQLLGCANI RVRETTREVL SSDISAVLYQ
PLFKALEAEL DVLFDGVLAP TDQAHDVEII FAEQAISLLR ALVERLDSPS HLGAASSVHL
GAVTLSFVKF MDGMPDTVNT LRVKIKVCQL CEVVNKRKEY LNPRDDVRIR NHLLEYIFGW
IVRPWSPHAD VNPHPATRHD EFQRVQKDLD KACLKSLAEL TFRLPLQPGD GQTDASTSEL
KSKMFHTYFS RFLSLLNHEP PEAGRNDHGP AISSRDEAKS SSELAITILS NILSANIDVG
LKHSLNIGYH QSIEMRTAFV RVLCNILVQG TEFSNLTDSA VSEKYDELLE LLTKDMTLVA
AVSIVCPSNE VDELSVSLLT IFEHRKKSFD LLETLIKQEI EETENESEIL RRTCVATKVL
SIYAKWKGQA YLKATLQEVV ERLMLTSKDL GLELDPGRVG SPDELQKNAL QLRIVAKLFI
DDICASSASI PSSFRKICSI ISTAVLPRFP EAKYTAVGAF IFLRFFCPAI VAPEVEGLLD
ASPSRELRRG LLLIAKVIQS LANNVLFGAK EHYMFPLNDF LTQNIYRVTT FLREISVPPE
NFDYGSTMEC FDFGSCVALH RFLYDHWDHV RQKLVTQERR DYVRSPAESS RGRSPVLEPL
RNLITNLGPP PLAVTWNRPQ VSANPPSLYS RFQDFMLRNA FRGTESFLTA RPVYDGGESK
DSLPIICIIL RHIDSDSIDY DTLLFCFLKI ASRLWHRPFG LLIDATCYQA QNEPQDNVLK
KLERLTPIEL SRNMSRIYVY NMNNAFTKCF RRLLRVSVKS ESSIFHPKNV EYHLIGSLQD
LQTHFHLSQL HLPKETISVV TDTRFVYQPV SRISKFRGQI EVVIKVGNQF VQITTTNKQE
VAPGYRLNTT VNDIYRLGEV DEAPTSMQTE DDSAFGLRVD NGKMVMCFTS PKKMDVLQSI
RTAKAKYGKD NRLPKPYERL IRPQDVPGTL LNLSLSNLSS SDHVLRRASY NLLGALCKAF
RFSAASRLMC MIDIAVPVTP AHFIVNVSQQ LARSEPQLTF DFLTEFFVGW DSFGDKQKPL
SLAYMAPWLP GLRTAVLTSD SDGDKGKEKI ASLFRKLIDI AVSDQFLSYT LEQVVWPAIF
LDETLLEIFL DELMKTALDF NMTEEALDAL SSVASSINTI TVRAKIISRL RKALNRTSLR
PTKYLPDNVV WPEICILLRF CVSLSFDNGV QSQLYLPEIF HIVTILGNTG SSDVRLLVHR
LLVNTVHAAC TSFALDESKL NRLRSTLDLL SEPRSDVFLA PATSLRDTAS MSTTQDSGPV
LAATETLASS LFEVCTLCAP SVDISNAWRS RWMSLVASTA FQNNPAVQPR AFAVMGCLAR
EGVDDDLLYQ VLVALRNSVG RLGDDANIDM FISIVTSLSK MMSKLPSASR YGLQLFWLAI
SLVRLVPPAL FNCSAQFLEA VLTNISTVNG MKGESMARLL VQGRSQLEDA ALPLDDVYGI
HFTHDNFHFA VCACLTRGLV DTTTRPSAMR VLSAFLEMVN SPSNDAGRPS PRIVSSPYMS
LIQARAANDE ELRDALWLAG INPATIGPGL SLRRKVQDLE QVKDRDHLLN TALELVDFQY
LEDAIQVRTL QWLTSLSTAR PSVLVPLCGP ISSILEDTLL HCQNASSLQA AHVLLQCLTS
NPSLNTALES PGMLDDILEE MGFGGLWRSC SFESSQQQDR ECFALTEKLI ELIIM
//
