ID   A0A3N3ZVJ5_9MICC        Unreviewed;       306 AA.
AC   A0A3N3ZVJ5;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha {ECO:0000313|EMBL:ROZ62368.1};
GN   ORFNames=EDL96_10260 {ECO:0000313|EMBL:ROZ62368.1};
OS   Kocuria soli.
OC   Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC   Kocuria.
OX   NCBI_TaxID=2485125 {ECO:0000313|EMBL:ROZ62368.1, ECO:0000313|Proteomes:UP000270616};
RN   [1] {ECO:0000313|EMBL:ROZ62368.1, ECO:0000313|Proteomes:UP000270616}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=M5W7-7 {ECO:0000313|EMBL:ROZ62368.1,
RC   ECO:0000313|Proteomes:UP000270616};
RA   Tuo L.;
RT   "Kocuria sp. M5W7-7, whole genome shotgun sequence.";
RL   Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ROZ62368.1}.
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DR   EMBL; RKMF01000013; ROZ62368.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3N3ZVJ5; -.
DR   OrthoDB; 9766715at2; -.
DR   Proteomes; UP000270616; Unassembled WGS sequence.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR   GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   PANTHER; PTHR11516:SF60; PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA; 1.
DR   PANTHER; PTHR11516; PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000270616}.
FT   DOMAIN          2..295
FT                   /note="Dehydrogenase E1 component"
FT                   /evidence="ECO:0000259|Pfam:PF00676"
SQ   SEQUENCE   306 AA;  31929 MW;  6226A9B001D420DE CRC64;
     MSEIRAFEDR LHKENTGGDI PGFIHLYAGE EAIAVGVCEH LTPADKIAST HRGHGHCIAK
     GSDIEGMMLE IFGRKEGLCH GKGGSMHIAD LATGMLGANG IVGGGPPITI GAALTAKYKG
     DGNVAVSFTG DGGSNQGLVL EAMNMAVVLN LPVVFVFENN GMGEATGAEF AVGAPSIAKR
     AEGFGLPAVT VDGTDFFAVH EAAGEAIERA RTGGGPSVIE AKCNRFYGHF EGDQALYRTP
     EQLEELKAKT DPLSIFRDRT DGVLDPAELA LIDSESEQRV DAAVATARAA ALPDPSDVDT
     DVYVSY
//