ID A0A3N4HSC7_ASCIM Unreviewed; 1167 AA.
AC A0A3N4HSC7;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=BJ508DRAFT_330870 {ECO:0000313|EMBL:RPA76722.1};
OS Ascobolus immersus RN42.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Ascobolaceae; Ascobolus.
OX NCBI_TaxID=1160509 {ECO:0000313|EMBL:RPA76722.1, ECO:0000313|Proteomes:UP000275078};
RN [1] {ECO:0000313|EMBL:RPA76722.1, ECO:0000313|Proteomes:UP000275078}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RN42 {ECO:0000313|EMBL:RPA76722.1,
RC ECO:0000313|Proteomes:UP000275078};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ML119739; RPA76722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4HSC7; -.
DR STRING; 1160509.A0A3N4HSC7; -.
DR Proteomes; UP000275078; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046486; P:glycerolipid metabolic process; IEA:UniProt.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd07216; Pat17_PNPLA8_PNPLA9_like3; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR46082:SF6; AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED; 1.
DR PANTHER; PTHR46082; ATP/GTP-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01734; Patatin; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF13424; TPR_12; 3.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000275078}.
FT DOMAIN 61..267
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 1167 AA; 132026 MW; 2829AC873B100941 CRC64;
MSPPTQITHQ LEDAIRDITK GKAETTNPYL SKRQTVVTVP PLVRKRPVNS SPLDTNGLCL
LSLDGGGVRG LSTLYILKLL MDELNEERRN EGLSRVKPCN VFDLIGGTST GGIIAIMLGR
LEMDVEECIE AYTTLMNGIF KKRSLRAVFA LLRGKVKGRF SSTHLEEAIQ KILLLRNITV
RELFHVPNAR KENRCKVFVC ATSTEMASIQ RLRSYRPRGE LPSGEPTICE AALATSAATS
FFDPVKIGHR VFVDGALGAN NPVEEVENEA MNIWCSNSER ETGNNADLQQ IVKCFVSIGT
GVPSPNAIKD SVMKLLSETL RKIATETERT EAKFMGRWQA KTTVDNRYFR FNVAHGLQSV
GIAEYKEKGT IEAATCDYLK HPSRRSKMSH CVNNLLQRES REEAFGAKEL QAIVSTGPWP
ERQPWIELTL PTRPVADPPP PHKAAVQHLR ELEDCLFSEK YQARVAVYGL GGAGKTQIAL
EFVFRMQERH PDLSVFWIPL NSPEAIQQAY EEVASKLGIA LDTEDKKNRV KSLVQARLNE
DNMGRWLLVF DNADAVDVWK ESCMGETKTS DFLDYLPAST KGDILFTTRS IKMVMEQMTG
DCIKQVEVKA MMIDEATAML EVWIGHKGLF VEEDAKLLVQ RLTCLPLAIA QAGGFIEQNS
VPILEYLELM DKEEESLLSR NFRLEGRYSD SKNPIATTWI ISFTKLQKDR PHAAEILKCC
SLLDPRNMPN RVFPQAESQV AQIDALGTLT AYSFLTERRE SRTYDMHRLV HIATENWLRH
TLESSEMTSW KLCMFIVFAA GFPDLDTYKG FREKERSSYL PQVKYVLRTD DANLNQDLGH
DSNSDRAKLP LRIRLGDYLQ HESRPEEREG VLRHVHALQT ELLGSDDPET LTSMNNIGAC
LSDQHKFKEA ETLLRQVLAK REEILGLKHC DTLSTLHCIA FSIGGQLDRK EEAVLEYRRV
LELRVEVLGA EHAETLGTLN NVAFALYHCK RFEESEKVFR EALEGRTKVL GPNHTDTLLS
LHNHVSALQR LKGRSKEAEA GYRKLIEHLK EVNGPEHTIT LSAMYGLAST LKTQKRFKES
EAGYREIWEI RSRLLGPEHR DTVYAKFTVA DLLWDQKDLH GAISMLEEAY DVFRRRLGDQ
DAFTREALEY LERWRAEAGN IARVQGS
//
