UniProt: A0A3N4IAI7

Database: UniProt
Entry: A0A3N4IAI7_ASCIM

LinkDB:  A0A3N4IAI7_ASCIM 
Original site:  A0A3N4IAI7_ASCIM

All links

Ontology (5)   
   GO (5)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (46)   
   InterPro (25)   
   Pfam (11)   
   PROSITE (4)   
   SMART (6)   
Literature (1)   
   PubMed (1)   
All databases (53)   

Download RDF

ID   A0A3N4IAI7_ASCIM        Unreviewed;      2600 AA.
AC   A0A3N4IAI7;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Putative polyketide synthase {ECO:0000313|EMBL:RPA81688.1};
GN   ORFNames=BJ508DRAFT_326147 {ECO:0000313|EMBL:RPA81688.1};
OS   Ascobolus immersus RN42.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC   Pezizales; Ascobolaceae; Ascobolus.
OX   NCBI_TaxID=1160509 {ECO:0000313|EMBL:RPA81688.1, ECO:0000313|Proteomes:UP000275078};
RN   [1] {ECO:0000313|EMBL:RPA81688.1, ECO:0000313|Proteomes:UP000275078}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RN42 {ECO:0000313|EMBL:RPA81688.1,
RC   ECO:0000313|Proteomes:UP000275078};
RX   PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA   Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA   Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA   Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA   Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA   Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA   Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA   Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA   Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA   Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT   "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT   truffle lifestyle.";
RL   Nat. Ecol. Evol. 2:1956-1965(2018).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; ML119677; RPA81688.1; -; Genomic_DNA.
DR   STRING; 1160509.A0A3N4IAI7; -.
DR   Proteomes; UP000275078; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775:SF29; ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   NADP {ECO:0000256|ARBA:ARBA00022857};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000275078};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          57..482
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          2518..2595
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2600 AA;  285420 MW;  3B85485311D3B2B1 CRC64;
     MAPSITNASD TNGHSNDSTH GMNYDQEDTR LPTSGVNGTQ NYNMTEEDFS SLDEDGMMPI
     AVVGLACRFP GEASNPERLW DMCANGRDAW SKIPNSRFNV DAFYHPDGDK AGTMNVKHGH
     FIEEDPAVFD APFFSITPTE AKAMDPQQRK LLESVYEALE NGGIPMEKTF GSQTSVYVGV
     FSKDYGELLL RDPETGPLYQ ATGNAMSTLS NRISYFFDFK GPSITLDTAC SSSLVALHLA
     CQSLRNGEAN QAIVAASNLI LSPDIMISMS NLHFLSPDGR SYTYDQRANG YARGEGIASV
     VLKPLKEALK AGDPIRAIIR GSGVGQDGNT PGITVPSSSA QESLIRSTYH KAKLPLSETR
     YFETHGTGTQ VGDPLEAGAI GRIFGPERSS VDPIYAGSVK TNIGHLESAS GLAGFIKAVL
     VLEKAVILPN LRFENPNSNL RLDEWNIKVP TKTIAWPRSG IRRASVNSFG FGGTNAHAIV
     DDAYHYLTSR GLSGNHRTLP EPPVHPLSAI AIQAPRSPSL HLGSSTRLRL FPISANDELA
     AKQVQDRLLG YLSTRKIPRE NEEQFLDDLA YTLSCRRSVL PWKLAYAGAS LDDLVASVKA
     GVKPSRSLPS PKIGYVFTGQ GAQWYSMGRE LIEAYPVFKS SLAACQKVLK GISQWSLMEE
     LLASRGESNI NKPSISQPLC TAVQIALVDL LRSWGVEPTF VVGHSSGEIT AAYTIGALDL
     KSAMLVSFHR GRLSELIPVR DPNMKGSMLA AGLGEEEAQS LVAPYGGKVS VACINSPSSV
     TFSGDESAID SIKAMLDHQG TFNRKLIVQA AYHSHQMNVI AEEYLASMSG LQLGESRKKI
     AMVSSVTRSL TGAEELCTPQ YWVRNMLSPV QFSNALRTAL VTTSKNSAAD MLVEIGPHSA
     LAGPIKDILK SANLSLQYGA TLTRNEDATS TMIDLARQFY TIGYPLNLDV LNSLDTDAIG
     TPRTLTDLPS YAWNHSVKHW QESRLSKHYR HRKFANHPLL GTLTADHNPI EPKWRNFISL
     TNQPWVEDHQ VASSIVYPGA GFVAMAIEAL NQLVPEAVTG FRLRDVTLGK ALVVTSEKPV
     ETVLVFRAYN ESARQSSKVW DEFKVYSYTD DPSNPIQEHC HGLISADREA AFNIVDHGRE
     TNKRARHTDY QFETLIKSFD LKDEVKVDDF YSNLVKAGLE YGPSFRNIKR LVADKAAPGI
     AYGEFELPDT KSLMPHGYEL PHVIHPATLD TCLQTMFAAI SSDASGIREP MVPTVIESIY
     ISKRIASAPG YRLRTRSTTQ RKGFRDIDAA ITATSMNNGV PLIEIVGLRC TALKGRAAIG
     LDDGEVAEPI RKLCYGTTWK ADPSFLTFEQ IERLCKIEET PKFTRAMIAE YEKVSLHYIR
     KAVETISPEA NLFPYHRIFL EWMHKAVGEV QDMPLLQGLD VTVDDALIKK VSSSSSEGRM
     LVRMGENLPR VLNKVIDPLS LMLQDDLLYD YYREAIGTDR SYIQMQQYID LLAYKNPNMT
     ILEIGSGTGG ASLPILNILG GNGDSNARFA SYDFTDISSG FFEKAQKNFG AWGSLVRFKK
     LDIENDPTTQ GFPEAGYDLI IAANVLHATK TIRNTMDNVK KLLKPGGKLV MMELTNLLLR
     GHIVFGNLPG WWLGAHEGRK WGPILSIDGW DQVLKDCGYT GVEGHVKEFD GDEHMCSVII
     STIPHGPAPP SAEVILVKPD GPYNHPVVNK LHAELQTQHN TVTVVNQDAI SSTDFSGKTC
     IFMAEAGFGL LYKIKEGDFK GIQKIVSSCK TLIWVTQGAA IDSPNPHVNL INGLARSIRS
     ENNSLCFVTL DLDAINPLPS DKAAKTVLSL YDHVIYEPAI LDTEFAERNG ILKVSRVTEA
     KDYNVAIASR CGRLPHYVEM KTFRTVTRPI RLEIGTPGLL DTLRFSELPT DRNPMEDDEV
     EIKIFASGLN FRDVMVAMGE LTYDFLGCEG SGVITKIGSN VKNVRVGSRV CTWMLGAFNS
     HIRNPSQLVQ VIPENMSFEI AATLPVVYCT AYYGLIDIAR LQKHETVLIH AAAGGVGQAA
     IMLAKWVGAE IFVTVGTLEK KKHLMETYGI PGDHIFSSRD TTFADGVMRM TDGKGVDVVL
     NSLAGEQLRK SWQCVAFFGR FIEMGKKDID VNTRLDMAPF IRNVTFASVD LSTVFAQNKP
     LGARLLKDVM DLVRNKVIKP VVPITIFPFS KVEEAFRYMA AGKHIGKVVL RPTEDPVPVR
     PPQEPNSELD PYASYMIVGG LGGLGKAIAQ WMVTRGARNL IFLSRSGSKE KHRLFFNSVE
     EQGCHSAVVA CDVANPIRLK VCLERLKREM PPIRGIIQAA MVLKDSIFEK MPVSDFHAAL
     RPKVTGSWNL HNMLPDSLEF FIMLSSSAGI GGNQSQSNYA AANAFQDALA AYRNSRGLAA
     TTLDLGMIKG AGYVAENPEA EAKLHKWGFF DIHLDEFLAM LDYAIQNPKA GVSKAQIMTG
     LSVKHLLASS SDLPPWALDP KFSHLIRTES STDTTAKEGQ TVATSLAEKL QSAENMDEAA
     EMICQTILEK LSKVLVIPLE DMDSSKTTHA YGVDSLVAVE LRNWLSRDAK ADVPVFEIMG
     SKSLAELARK TAERSKVLKF
//

DBGET integrated database retrieval system