ID A0A3N4J2J9_9PEZI Unreviewed; 867 AA.
AC A0A3N4J2J9;
DT 13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT 13-FEB-2019, sequence version 1.
DT 13-SEP-2023, entry version 16.
DE RecName: Full=Rho-GTPase-activating protein 8 {ECO:0008006|Google:ProtNLM};
GN ORFNames=L873DRAFT_1716638 {ECO:0000313|EMBL:RPA90781.1};
OS Choiromyces venosus 120613-1.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Pezizomycetes;
OC Pezizales; Tuberaceae; Choiromyces.
OX NCBI_TaxID=1336337 {ECO:0000313|EMBL:RPA90781.1, ECO:0000313|Proteomes:UP000276215};
RN [1] {ECO:0000313|EMBL:RPA90781.1, ECO:0000313|Proteomes:UP000276215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=120613-1 {ECO:0000313|EMBL:RPA90781.1,
RC ECO:0000313|Proteomes:UP000276215};
RX PubMed=30420746; DOI=10.1038/s41559-018-0710-4;
RA Murat C., Payen T., Noel B., Kuo A., Morin E., Chen J., Kohler A.,
RA Krizsan K., Balestrini R., Da Silva C., Montanini B., Hainaut M.,
RA Levati E., Barry K.W., Belfiori B., Cichocki N., Clum A., Dockter R.B.,
RA Fauchery L., Guy J., Iotti M., Le Tacon F., Lindquist E.A., Lipzen A.,
RA Malagnac F., Mello A., Molinier V., Miyauchi S., Poulain J., Riccioni C.,
RA Rubini A., Sitrit Y., Splivallo R., Traeger S., Wang M., Zifcakova L.,
RA Wipf D., Zambonelli A., Paolocci F., Nowrousian M., Ottonello S.,
RA Baldrian P., Spatafora J.W., Henrissat B., Nagy L.G., Aury J.M.,
RA Wincker P., Grigoriev I.V., Bonfante P., Martin F.M.;
RT "Pezizomycetes genomes reveal the molecular basis of ectomycorrhizal
RT truffle lifestyle.";
RL Nat. Ecol. Evol. 2:1956-1965(2018).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; ML120514; RPA90781.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A3N4J2J9; -.
DR STRING; 1336337.A0A3N4J2J9; -.
DR Proteomes; UP000276215; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04399; RhoGAP_fRGD2; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 2.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23065; PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1; 1.
DR PANTHER; PTHR23065:SF17; RHO-GTPASE-ACTIVATING PROTEIN RGD2; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Reference proteome {ECO:0000313|Proteomes:UP000276215}.
FT DOMAIN 2..440
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 240..309
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 474..672
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 164..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..867
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..753
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..793
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..817
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 867 AA; 95505 MW; EAB91063EF10D318 CRC64;
MPGFADSFWS GDYAGGLGVL FGKLQQGVIE NQQIVQIAKL RADAEDAYGQ RLGTIPPGAE
KPGGFGRDDG ASVRKAFDGL KKEMDDAGKN HRKVADNIRQ LVINPFSKWC EAHEERIINS
HDDLQGQIKN HDKQAEAVKK LRSHYFNKCR LVEDLEEETK FIQVPAPGTP SSATSPPPTA
PAAVATATPE IKLPEPEDPE DDEPLEIGDL FYQPVEVKKM LSHMLETIPL GEVKVAILGT
YQNVSTGENI VKFIQENLGA TSISHAERIG QDLVTHGFLR LVGSVGNTFA NSPKLHYQWR
PKTFQLTGKP EKPVQKAAKA LENGDSVESP TMAYVGDYLG GLLTNQHPGE TPGDRLRREA
SEADERYKAG VKKLDLMRCA LEESMMEHLK FMERCELDRL KAIKAVILDL SGAISNVIPS
IQATVDNMLL YQETIQPLGD LRYMLESYRT GSYVPKVVTY ESYYNSVDEQ TFGVDLEARA
RADRKRVPII ITSILTYLDH HYPDLEGDEA RRGIWLVDVP LAATHHLRNA INTGKAIPKE
VLATYEIPIV ASVLKLYLLE LPDSLVSSHK YEIIKTVYTT HGTEGEENRR LAVIQNTLGS
LPLTNIATLD AITTHFTRLI ELTSADEAYV TSLAHGLSSC ILRPRVESSL TQHERHAYRL
VRDLFAHKEQ IFGELKRAST LNSGRARAIS TDESQRRAHV EARNRAVIGA ARSRPSSPAP
SSRHRREVST DGGNRFPIQT SPTSGSPRTS RYRPSSLEVP GGASSLDRDQ KLDSEVEAPR
VSGEPESFTH HESEESSPAT PTAGLEKSNS LTRKSHAGGG STRFPRKGAN LVRSAAGGPK
RDSLSMGGSF EEERPTGVSL TDRPMDD
//
